正高级职称人员

基本介绍

黎孟枫 教授
病毒致癌与肿瘤发生的分子机制;分子病毒学与分子肿瘤学 中山大学副校长,中山医学院院长
博士导师,硕士导师
微生物学;分子医学 87331969
中山二路74号中山大学北校区中山医学院
limf@mail.sysu.edu.cn

个人简介:

    “长江学者”特聘教授,中山大学副校长兼中山医学院院长。1986年毕业于中山医科大学临床医学专业毕业,获医学学士学位。1986-1991年就读中山医科大学与中国预防医学科学院北京病毒学研究所(CAPM-BIV)病毒基因工程国家重点实验室联合培养研究生,获医学博士学位。1991-1993年任CAPM-BIV病毒基因工程国家重点实验室助理研究员。1993年前往美国匹兹堡癌症研究所接受博士后训练,并于1997年在该所担任研究助理教授(Research Assistant Professor,非独立职位)。2000年起受聘于匹兹堡大学医学院病理系,任助理教授(Assistant Professor,独立职位),一直在美国从事医学分子病毒学、分子肿瘤学和细胞生物学的教学与科研,研究领域主要为病毒致病与致癌、以及肿瘤发生发展的分子机制,并讲授医学生“Molecular Pathogenesis of Infectious Diseases”和博士生“Angiogenesis: Physiology and Pathological Significance”课程。2005年受聘为“长江学者”特聘教授,全职归国到中山医学院工作。黎孟枫教授近年在中山大学主要致力于阐明肿瘤发生与病毒感染、炎症过程的关系,以及相关的信号控制机理,主要学术重点是NF-κB信号通路所涉及的新调控分子及其工作机制,以及由此产生的生物学效应和在肿瘤、病毒性疾病上的临床意义,最近发现了NF-κB的激活与多种病毒感染相关基因之间的相互作用,以及miRNA对NF-κB激活的表观遗传学调控作用,深入研究了这些相互作用的生物学意义。作为上述调控网络的理论意义的延伸,还研究了NF-κB调控分子在病毒感染和肿瘤恶化中的临床意义,并在此基础上寻找病毒感染和恶性肿瘤诊断、预后判定新分子标志物及治疗新靶点。上述研究的部分结果最近发表在Cancer Research., Oncogene, Journal of Pathology, American Journal of Pathology, Clinical Cancer Research期刊上。

学术论著与教材:

近三年发表的学术论文:

1. Jun Li, Le Yang, Libing Song, Huaping Xiong, Lan Wang, Xi Yan, Jie Yuan, Jueheng Wu, Mengfeng Li*. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene, 28(36): 3188-3196, 2009.

2. Jun Li, Liyun Gong, Libing Song, Lili Jiang, Liping Liu, Jueheng Wu, Jie Yuan, Junchao Cai, Mian He, Lan Wang, Musheng Zeng, Shiyuan Cheng*, Mengfeng Li*. Oncoprotein Bmi-1 Renders Apoptotic Resistance to Glioma Cells through Activation of the IKK-NF-kB Pathway. American Journal of Pathology 176(2): 699-709, 2010.

3. Liping Liu, Jueheng Wu, Zhe Ying, Baixue Chen, Libing Song, Jie Yuan, Jun Li*, Mengeng Li*. Astrocyte elevated gene-1 (AEG-1) Upregulates Matrix Metalloprotease-9 and Induces Human Glioma Invasion. Cancer Research, 70(9): 3750-3759, 2010.

4. Xiaofan Ding, Lifang Jiang, Changwen Ke, Zhan Yang, Chunliang Lei, Kaiyuan Cao, Jun Xu, Lin Xu, Xingfen Yang, Yonghui Zhang, Ping Huang, Weijun Huang, Xun Zhu, Zhenjian He, Liping Liu, Jun Li, Jie Yuan, Jueheng Wu, Xiaoping Tang*, Mengfeng Li*. Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates. Virus Genes, 41:329–340, 2010.

5. Hongyu Guan, Heng Zhang, Jueheng Wu, Jie Yuan, Zhengsong Huang* and Mengfeng Li*. IKBKE is overexpressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-κB. Journal of Pathology. 223: 436–445, 2011.

6. Libing Song*, Lan Wang, Jun Li, Huaping Xiong, Jueheng Wu, and Menfeng Li*. Sam68 Upregulation Correlates with, and Its Downregulation Inhibits, Proliferation and Tumorigenicity of Breast Cancer Cells. Journal of Pathology, 222 (3): 227–237, 2010.

7. Libing Song*, Huaping Xiong, Jun Li, Wengting Liao, Lan Wang, Jueheng Wu, Menfeng Li*. Sphingosine kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-κB Pathway in Human Non-small Cell Lung Cancer. Clinical Cancer Research. 17(7): 1839-1849, 2011.

8. Shuo Zhang, Mifang Liang, Wen Gu, Chuan Li, Fang Miao, Xiaofang Wang, Cong Jin, Li Zhang,Fushun Zhang, Quanfu Zhang, Lifang Jiang, Mengfeng Li and Dexin Li* Vaccination with dengue virus-like particles induces humoral and cellular immune responses in mice. Virology Journal, 8:333, 2011.

9. Hongyu Guan, Junchao Cai, Nu Zhang, Jueheng Wu, Jie Yuan, Jun Li and Mengfeng Li*. Sp1 is upregulated in human glioma, promotes MMP-2-mediated cell invasion and predicts poor clinical outcome. International Journal of Cancer, 130, 593–601, 2012.

10. Yi Yang, Jueheng Wu, Hongyu Guan, Junchao Cai, Lishan Fang, Jun Li, and Mengfeng Li*. MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2, FEBS Letter, 586 (20): 3608-3612, 2012.

11. Ting Lei, Kit-San Yuen, Rui Xu, Sai Wah Tsao, Honglin Chen, Mengfeng Li, Kin-Hang Kok, Dong-Yan Jin*. Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma, International Journal of Cancer, 133(1):79-87, 2012.

12. Lili Jiang, Chuyong Lin, Libing Song, Jueheng Wu, Baixue Chen, Zhe Ying, Lishan Fang, Xiao Yan, Mian He, Jun Li,* and Mengfeng Li*. MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop. Journal of Clinical Investigation. 122 (1): 33–47, 2012.

13. Junchao Cai, Hongyu Guan, Lishan Fang, Yi Yang, Xun Zhu, Jie Yuan, Jueheng Wu, and Mengfeng Li*. MiR-374a Promotes Epithelial-Mesenchymal Transition (EMT) and Metastasis of Breast Cancer through Activation of Wnt/β-catenin signaling. Journal of Clinical Investigation, 123(2):566-79, 2013.

14. Lin Xu, Xia He, Dingmei Zhang, Fashen Feng, Zhu Wang, Linlin Guan, Jueheng Wu, Rong Zhou, Bojian Zheng, Kwokyung Yuen, Mengfeng Li,and Kaiyuan Cao*. Surveillance and genome analysis of Human Bocavirus in patients with respiratory infection in Guangzhou,China. PLoS ONE, 7(9): e44876. doi:10.1371/journal.pone.0044876.

15. Junchao Cai, Jueheng Wu, Huizhong Zhang, Lishan Fang, Rong Li, Yongbo Huang, Yi Yang, Xun Zhu, and Mengfeng Li*. Downregulation of miR-186 Correlates with Poor Survival in Non-small Cell Lung Cancer and Contributes to Tumorigenesis via Interfering with Cell Cycle Regulation. Cancer Research, 73(2): 756-766, 2013.

16. Zhe Ying, Yun Li, Jueheng Wu, Xun Zhu, Yi Yang, Han Tian, Wei Li, Bo Hu, Shiyuan Cheng and Mengfeng Li*. Loss of miR-204 Expression Enhances Glioma Migration and Stem Cell-Like Phenotype. Cancer Research, 73(2): 990-999, 2013.

17. Junchao Cai, Lishan Fang, Yongbo Huang, Rong Li, Jie Yuan, Yi Yang, Xun Zhu, Baixue Chen, Jueheng Wu, and Mengfeng Li *. MiR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer. Cancer Research, 1;73(17):5402-5415, 2013.

18. Churong Lin, Aibin Liu, Jinrong Zhu, Xin Zhang, Geyan Wu, Pengli Ren, Jueheng Wu, Mengfeng Li, Jun Li*, and Libin Song*. miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma. Nature communications ,5:4620, 2014.

19. Xun Zhu, Zhenjian He, Yiwen Hu, Weitao Wen, Cuiji Lin, Jianchen Yu, Jing Pan, Ran Li, Haijing Deng, Shaowei Liao, Jie Yuan, Jueheng Wu, Jun Li, Mengfeng Li*. MicroRNA-30e* Suppresses Dengue Virus Replication by Promoting NF-kB–Dependent IFN Production. PLoS Neglected Tropical Diseases. 8 (8): e3088, 2014.

20. Yun Li, Wei Li, Zhe Ying, Han Tian, Xun Zhu, Jun Li, and Mengfeng Li*. Metastatic Heterogeneity of Breast Cancer Cells Is Associated with Expression of a Heterogeneous TGFβ-Activating miR424-503 Gene Cluster. Cancer Research, 74(21):6107-18, 2014.

21. Dingmei Zhang, Zhenjian He, Lin Xu, Xun Zhu, Jueheng Wu, Weitao Wen, Yun Zheng, Yu Deng, Jieling Chen, Yiwen Hu, Mengfeng Li*, Kaiyuan Cao*. Epidemiology characteristics of respiratory viruses found in children and adults with respiratory tract infections in southern China. International Journal of Infectious Diseases. 25:159-164, 2014.

22. Weitao Wen, Zhenjian He, Qinlong Jing, Yiwen Hu, Cuiji Lin, Rui Zhou, Xiaoqun Wang, Yangfan Su, Jiehao Yuan, Zhenxin Chen, Jie Yuan, Jueheng Wu, Jun Li, Xun Zhu*,and Mengfeng Li*. Cellular microRNA-miR-548g-3p modulates the replication of dengue virus. The Journal of infection S0163-4453(14)00372-7, 2014.

学术兼职:

        黎孟枫教授现还担任国务院学位委员会学科评议组(基础医学)成员、中国微生物学会《病毒学报》副总编、美国癌症学会会员、美国微生物学会会员、国际自然免疫学会会员等学术兼职。

其 他:

主持在研基金项目:

1.     微小RNA与肿瘤,973课题

2.     海洋来源的抗肿瘤候选药物SZ-685C的研究,国家新药科技重大专项

3.     广东省传染病病原谱流行规律研究(监测平台),国家传染病科技重大专项

4.     原癌基因AEG-1诱导乳腺癌早期转移的分子机制,国家自然科学基金面上项目

5.     驱动脑胶质瘤血管新生的新机制:AEG-1激活的信号转导,国家自然科学基金面上项目

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