副高级职称人员

基本介绍

汤勇波 副教授
心脑血管研究
博士导师,硕士导师
药理学 020-87334740
tangyb@mail.sysu.edu.cn

个人简介:

 2007年毕业于中山大学中山医学院获药理学博士学位,毕业后留校任教师,2012年晋升为药理学副教授。

研究方向:离子通道在疾病中的作用机制,心血管药物靶点开发。

科研基金:2008年来先后主持国家自然科学基金, 教育部博士点基金, 广东省科技计划项目,广东省医学科学基金, 高校基本科研业务费中山大学青年教师培育项目各一项。作为核心成员参与多项国家自然科学基金面上及重点项目,973计划。

 

学术论著与教材:

1.      Huang LY, He Q, Liang SJ, Su YX, Xiong LX, Wu QQ, Wu QY, Tao J, Wang JP, Tang YB, Lv XF, Liu J,Guan YY, Pang RP, Zhou JG. ClC-3 chloride channel/antiporter defect contributes to inflammatory bowel disease in humans and mice.. 2014 Jan 17.. (SCI, IF>10) Gut

2.      Zheng LY, Li L, Ma MM, Liu Y, Wang GL, Tang YB, Zhou JG, Lv XF, Du YH, Guan YY. Deficiency of Volume-Regulated ClC-3 Chloride Channel Attenuates Cerebrovascular Remodeling in DOCA-salt Hypertension.Cardiovasc Res. 2013 Jun 19. PMID:23786998. (SCI, IF>6)

3.      Wang XG, Tao J, Ma MM, Tang YB, Zhou JG, Guan YY.Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells. Cardiovasc Res. 2013 Jun 1;98(3):469-78. PMID:23536605. (SCI, IF>6)

4.      Xing X, Tang YB, Yuan G, Wang Y , Wang J, Yang Y, Chen M. The prognostic value of E-cadherin in gastric cancer: a meta-analysis. Int J Cancer 2013;132(11):2589-96 PMID: 23163395 (并列第一SCI, IF>5.4)

5.      Yang H, Huang LY, Zeng DY, Huang EW, Liang SJ, Tang YB, Su YX, Tao J, Shang F, Wu QQ, Xiong LX, Lv XF, Liu J, Guan YY, Zhou JG. Decrease of Intracellular Chloride Concentration Promotes Endothelial Cell Inflammation by Activating Nuclear Factor-κB Pathway. Hypertension. 2012;60(5):1287-93 PMID: 23006728 (SCI, IF>6.2)

6.      Zhang Z, Wang M, Fan XH, Chen JH, Guan YY, Tang YB. Upregulation of TRPM7 Channels by Angiotensin II Triggers Phenotypic Switching of Vascular Smooth Muscle Cells of Ascending Aorta. Circ Res. 2012;111:1137-1146. PMID:22896586 (通讯作者SCI, IF>9.5).

7.      Huang EW, Xue SJ, Zhang Z, Zhou JG, GuanYY, Tang YB. Vinpocetine inhibits breast cancer cells growth in vitro and in vivo. Apoptosis. 2012 17:1120–1130. PMID:22729609.(通讯作SCI, IF>4.7).

8.      Wang M, Yang H, Zheng LY, Zhang Z, Tang YB, Wang GL, Du YH, Lv XF, Liu J, Zhou JG, GuanYY. Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension through promoting basilar smooth muscle cell proliferation. Circulation. 2012;125:697-707. PMID:22215857 (SCI, IF>14)

9.      Zhang Z, Wang M, Xue SJ, Liu DH, Tang YB. Simvastatin Ameliorates Angiotensin II-Induced Endothelial Dysfunction Through Restoration of Rho-BH4-eNOS-NO Pathway. Cardiovasc Drugs Ther. 2012 Feb;26(1):31-40 PMID:22083280 (通讯作者SCI, IF>3.1).

10. Li SY, Wang XG, Ma MM, Liu Y, Du YH, Lv XF, Zhou JG, Tang YB, Guan YY. Ginsenoside-Rd potentiates apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through the mitochondrial pathway. Apoptosis. 2012 Feb;17(2):113-20. PMID:22076303 (共同通讯作者SCI, IF>4.7).

11. Tu YS, Kang XL, Zhou JG, Lv XF, Tang YB, Guan YY. Involvement of Chk1-Cdc25A-cyclin A/CDk2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells. Eur J Pharmacol. 2011;670:356–364. PMID:21958871 (共同通讯作者SCI, IF>2.7).

12. Qian Y, Du YH, Tang YB, Lv XF, Liu J, Zhou JG, Guan YY. ClC-3 chloride channel prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through mitochondria dependent pathway. Apoptosis. 2011;16(5):468-77. PMID:21373935 (SCI, IF>4.7)

13. Hong L, Xie ZZ, Du YH, Tang YB, Tao J, Lv XF, Zhou JG, Guan YY. Alteration of volume-regulated chloride channel during macrophage-derived foam cell formation in atherosclerosis. Atherosclerosis. 2011;216(1):59-66. PMID:21338988 (SCI, IF>4.5)

14. Du RH, Tang YB, Zhou JG, Guan YY. Tween 80 inhibits volume-regulated chloride channel and cell proliferation in rat basilar artery smooth muscle cells. J.Pharm.Pharmacol. 2011;63(2):253-60 (并列第一,SCI,IF>1.8)

15. Li J, Xie ZZ, Tang YB. Genistein prevents myocardial hypertrophy in 2 kidney 1 clip renal hypertensive rats by restoring eNOS pathway. Pharmacology. 2010; 86(4):240-248. (通讯作者,SCI, IF>1.8)

16. Liu YJ, Wang XG, Tang YB, Chen JH, Lv XF, Zhou JG, Guan YY. Simvastatin Ameliorates Rat Cerebrovascular Remodeling During Hypertension via Inhibition of Volume-Regulated Chloride Channel. Hypertension. 2010;56:445-452. (并列第一,SCI, IF>6.0)

17. Tang YB, Liu YJ, Zhou JG, Wang GL, Qiu QY, Guan YY. Silence of ClC-3 chloride channel inhibits cell proliferation and the cell cycle via G/S phase arrest in rat basilar arterial smooth muscle cells. Cell Prolif. 2008 Oct;41(5):775-85. (第一作者,SCI, IF>3.0)

18. Tang YB, Zhou JG, Guan YY. Volume-regulated chloride channels and cerebral vascular remodelling. Clin Exp Pharmacol Physiol. 2010 Feb;37(2):238-42. PMID: 20178504(第一作者SCI, IF>2.2

19. Li J, Xie ZZ, Tang YB, Zhou JG, Guan YY. Ginsenoside-Rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoE knockout mice.(并列第一,SCI:IF>2.8) Eur J Pharmacol. 2011;652(1-3):104-10.

 

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