正高级职称人员

基本介绍

Dmitry Gabrilovich 教授
肿瘤免疫耐受机制
博士导师,硕士导师
免疫学 87332749
中山二路74号科技楼东1330
gabrilovich@mail.sysu.edu.cn

个人简介:

        Dmitry I. Gabrilovich,国际知名免疫学家,中组部“外专千人计划”入选者。1989年获得俄罗斯中央流行病学研究所博士学位,先后在美国南佛罗里达大学、威斯达研究所和宾夕法尼亚大学担任教授。Gabrilovich教授是 MDSC(髓系抑制性细胞)的发现者及定义者,在MDSC的基础研究﹑转化医学及临床应用方面做出了一系列引领国际前沿的原创性工作。在包括Nature Medicine, Nature Immunology, Immunity等国际免疫学主流期刊发表论文230余篇,h-index 指数为68 (截止2015年1月),连续多年被评为世界上发表论文引用率最高的作者之一(基于ISI Thomson Reuters系统)。
        Gabrilovich教授主要研究方向为:调节性髓系细胞在肿瘤免疫耐受中的作用及其分子调控机制研究,并探讨基于此的肿瘤免疫治疗新策略和新靶点。

学术论著与教材:

1 - Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of immune system. Nat. Rev. Immunol. 2009 Mar; 9(3): 162-174.
2 - Zhou J, Cheng P, Youn JI, Cotter MJ, Gabrilovich DI. Notch and Wnt signaling cooperate in regulation of dendritic cell differentiation. Immunity. 2009, 30, 845-859.
3 - Ramakrishnan R, Assudani D, Nagaraj S, Hunter T, Cho HI, Antonia S, Altiok S, Celis E, Gabrilovich DI. Mechanism of combined effect of cancer immunotherapy and chemotherapy. J Clin. Invest.2010, 120: 1111-1124.
4 - Herber DL, Cao W, Nefedova Y, Novitskiy SV, Nagaraj S, Tyurin VA, Corzo A, Cho HI, Celis E, Lennox B, Knight SC, Padhya T, McCaffrey TV, McCaffrey JC, Antonia S, Fishman M, Ferris RL, Kagan VE, Gabrilovich DI. Lipid accumulation and dendritic cell dysfunction in cancer. Nat. Med. 2010; 16, 880-886.
5- Corzo CA, Condamine T, Lu L, Cotter MJ, Youn JI, Cheng P, Cho HI, Celis E., Quiceno DG, Padhya T,McCaffrey TV, McCaffrey JC, GabrilovichDI. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 2010, 207, 2439-2453.
6 - Lu T, Ramakrishnan R, Altiok S, Youn JI, Cheng P, Celis E, Pisarev V, Sherman S, Sporn MB, GabrilovichDI. Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells. J. Clin. Invest. 2011, 121(10):4015-29.
7 - Gabrilovich DI, Ostrand-Rosenberg S., Bronte, V. Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 2012, 12, 253-268.
8 - Youn JI, Kumar V, Collazo M, Nefedova Y, Condamine T, Cheng P, Villagra A, Antonia S, McCaffrey JC, Fishman M, Sarnaik A, Horna P, Sotomayor E, Gabrilovich DI. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat. Immunol. 2013, 14: 211-220.
9 - Talmadge EJ, Gabrilovich DI. History of myeloid-derived suppressor cells. Nat. Rev. Cancer. 2013, 10:739-752.
10 - Cheng P, Kumar V, Liu H, Youn JI, Fishman M, Sherman S, Gabrilovich D. Effects of Notch signaling on regulation of myeloid cell differentiation in cancer. Cancer Res. 2014 74(1):141-152.
11 - Ramakrishnan R, Tuyrin VA, Veglia F, Condamine T, Amoscato A, Mohammadyani D, Johnson JJ, Min Zhang L, Klein-Seetharaman J, Celis E, Kagan VE, Gabrilovich DI. Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer. J Immunol. 2014, 192: 2920-2931.
12- Condamine T, Kumar V, Ramachandran IR, Youn JI, Celis E, Finnberg N, El-Deiry WS, Winograd R, Vonderheide RH, English NR, Knight SC, Yagita H, McCaffrey JC, Antonia S, Hockstein N, Witt R, Masters G, Bauer T, Gabrilovich DI. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. J Clin Invest. 2014, 124, 2626-2639.
13 - Condamine T, Gabrilovich DI. Can the Suppressive Activity of Myeloid-Derived Suppressor Cells Be "Chop"ped? Immunity 2014; 41(3):341-2.
14 - Ortiz M, Kumar V, Martner A, Mony S, Donthireddy L, Condamine T, Seykora J, Knight S, Malietzis G, Lee G, Moorghen M, Lenox B, Luetteke N, Celis E, Gabrilovich D. Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17 producing CD4+ T cells. J Exp Med. 2015, 212, 351-367.
15 - Marvel D, Gabrilovich DI. Myeloid -derived suppressor cells in the tumor microenvironment: expect the unexpected. J Clin Invest. 2015 Jul 13:1-9.
 

其 他:

本团队长期招聘博士后,专职科研人员(研究助理,副研究员,研究员),欢迎应聘;同时每年招生硕士生和博士生,欢迎报考。

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