正高级职称人员

基本介绍

田国宝 教授
细菌耐药
博士导师,硕士导师
微生物学、免疫学、病原生物学 020-87335387
广州市越秀区中山二路74号中山大学北校区中山医学院免疫学教研室
tiangb@mail.sysu.edu.cn

个人简介:

    细菌耐药问题一直是困扰医院临床的一大难题,“超级细菌”的不断出现更是引起公众的极大恐慌,成为全球普遍关注的公共安全问题。2014年,世界卫生组织(WHO)发布全球细菌耐药监测报告显示:2013年全球直接死于耐药细菌感染的人数超过100万人,并预测照此趋势到2050年死亡人数将达1000万人/年,超过癌症死亡人数。鉴于细菌耐药问题的严重性,2015年-2016年美英和我国等多国政府相继发布《遏制细菌耐药国家行动计划》,2016年9月二十国集团领导人杭州峰会和联合国大会专门就细菌耐药问题发布联合公报和举行高级别会议,旨在透过全球的共同努力有效解决细菌耐药问题。 
   田国宝,国家优青,广东省杰青。博士,博士生、硕士生导师,中山大学“百人计划”人才,中山大学中山医学院教授。一直从事细菌耐药机制研究,重点致力于临床“最后一线”药物多粘菌素和临床使用最广的β-内酰胺类药物的耐药分子机制研究。研究成果先后在Lancet Infectious Diseases,Emerging Infectious Diseases,Antimicrobial Agents and Chemotherapy,Journal of Antimicrobial Chemotherapy等本领域国际顶尖和主流期刊上发表SCI论文32篇,其中第一和通讯作者论文18篇,参编专著1部,以第一发明人申请6项专利。主持和作为核心骨干参与包括国家自然科学基金、国家重点研发计划等基金12项。并入选“广东特支计划”百千万工程青年拔尖人才、广州市珠江科技新星、高等院校“千百十工程”第七批培养对象、高校基本科研业务费青年教师重点培育等人才项目。

研究兴趣
1.临床病原细菌对β-内酰胺类药物、多粘菌素类药物和替加环素耐药机制研究
2.结核分枝杆菌耐药机制研究
3.耐药基因的分子生物学检测方法建立
4.细菌耐药阻断剂和新型抗生素复方制剂研发

科研项目
1. “广东特支计划”百千万工程青年拔尖人才,2016,细菌耐药性
2.高校基本科研业务费青年教师重点培育项目,16ykzd09,耐碳青霉稀类药物“超级细菌”的耐药传播分子机制及临床治疗,主持
3.国家自然科学基金项目,81471988,新型超广谱β-内酰胺酶PME耐药传播分子机制,主持
4.国家重点研发计划,2016YFC1200100,输入性传染病的输入机制与播散规律,核心骨干
5.广东省科技发展专项,2016A020219002,动物和人源产碳青霉烯酶超级细菌的流行病学和传播机制比较研究,主持
6.广州市珠江新星专项,2014J2200038,广东产新型超广谱β-内酰胺酶PME耐药传播分子机制及风险,主持
7.广东省自然科学基金项目,S2013010015810,广东PME酶学功能及耐药传播分子机制,主持
8.国家重大科技专项“十二五”计划课题,2013ZX10003001,结核病新型诊断产品研发及其产业化,子任务负责人
9.广东省海洋经济创新发展区域示范专项项目,GDHY2012-01-001,海洋生物天然产物化合物库,参与
10.国家自然科学基金项目,81201325,产CTX-M-15多重耐药E.coliST131耐药传播分子机制研究,主持
11.广东省自然科学基金项目,广东地区产CTX-M-15多重耐药E.coliST131耐药传播分子机制研究,主持

招聘信息
本实验室常年招聘以下研究人员:
1. 特聘研究员:38周岁以下,博士,有4项及以上代表性学术成果。工资税前30-36万/年
2. 特聘副研究员:38周岁以下,博士,有2项及以上代表性学术成果。工资税前19-25万/年
3. 助理研究员:35周岁以下,博士或特别优秀的硕士。工资税前14-16万/年
4. 博士后:35周岁以下,国内外知名高校或研究机构的博士毕业生。工资税前12-16万/年
欢迎有医学、生命科学、生物信息学等相关研究背景的人员与本人联系。

学术论著与教材:

1.Lan-Lan Zhong,Nicole Stoesser,Yohei Doi,Cong Shen,Xi Huang,Guo-Bao Tian*(通讯作者),Carriageof β-lactamase-producing Enterobacteriaceae by Chinese travellers,Lancet Infectious Diseases,2017.2.1,17.影响因子22.433
2.Yang Wang*, Guo-Bao Tian*(共同第一作者), Rong Zhang, Yingbo Shen, Jonathan M. Tyrrell, Xi Huang, Hongwei Zhou, Lei Lei, Hong-Yu Li, Yohei Doi, Ying Fang, Hongwei Ren, Lan-Lan Zhong, Zhangqi Shen, Kun-Jiao Zeng, Shaolin Wang, Jian-Hua Liu, Congming Wu, Timothy R. Walsh, Jianzhong Shen.Clinical associations and molecular epidemiology of mcr-1-positive Escherichia coli in patients and as normal human flora from China: an epidemiology and clinical study. Lancet Infectious Diseases.accepted. 影响因子22.433
3.Lan-Lan Zhong, Yan-Fen Zhang, Yohei Doi, Xi Huang, Xue-Fei Zhang, Kun-Jiao Zeng, Cong She, Sandip Patil, Yong Xing, Yutian Zou, Guo-Bao Tian*(通讯作者). Co-production of MCR-1 and NDM-1 by colistin-resistant Escherichia coli isolated from a healthy individual. Antimicrobial Agents and Chemotherapy. 2016 Nov 7. pii: AAC.01962-16. 影响因子4.451.
4.Zhang XF, Doi Y, Huang X, Li HY, Zhong LL, Zeng KJ, Zhang YF, Patil S, Tian GB(通讯作者). Possible Transmission of mcr-1-Harboring Escherichia coli between Companion Animals and Human. Emerg Infect Dis. 2016 Sep 15;22(9). doi: 10.3201/eid2209.160464. 影响因子6.994.
5.Zeng KJ, Doi Y, Patil S, Huang X, Tian GB(通讯作者). Emergence of the Plasmid-Mediated mcr-1 Gene in Colistin-Resistant Enterobacter aerogenes and Enterobacter cloacae. Antimicrob Agents Chemother. 2016 May 23;60(6):3862-3. doi: 10.1128/AAC.00345-16. 影响因子4.451.
6.Tian GB(第一作者), Jiang YQ, Huang YM, Qin Y, Feng LQ, Zhang XF, Li HY, Zhong LL, Zeng KJ, Patil S, Xing Y, Huang X. Characterization of CTX-M-140, a Variant of CTX-M-14 Extended-Spectrum β-Lactamase (ESBL) with Decreased Cephalosporin Hydrolytic Activity, from Cephalosporin-Resistant Proteus mirabilis. Antimicrob Agents Chemother. 2016 Aug 1. pii: AAC.00822-16. 影响因子4.451.
7.Huang YM, Zhong LL, Zhang XF, Hu HT, Li YQ, Yang XR, Feng LQ, Huang X, Tian GB(通讯作者). NDM-1-Producing Citrobacter freundii, Escherichia coli, and Acinetobacter baumannii Identified from a Single Patient in China. Antimicrob Agents Chemother. 2015 Aug;59(8):5073-7. doi: 10.1128/AAC.04682-14.
8.Guo-Bao Tian, Ying-Min Huang, Zhi-Li Fang, Yun Qing, Xue-Fei Zhang, Xi Huang. CTX-M-137, a Hybrid of CTX-M-14-Like and CTX-M-15-Like β-Lactamases Identified in anEscherichia coli Clinical Isolate. J Antimicrob Chemother. 2014;69(8):2081-5.
9.Qing Y, Cao KY, Fang ZL, Huang YM, Zhang XF, Tian GB(共同通讯作者), Huang X. Outbreak of PER-1 and Diversity of β-Lactamases among Ceftazidime-Resistant Pseudomonas aeruginosa Clinical Isolates in China. J Med Microbiol. 2014 Jan 7. doi: 10.1099/jmm.0.069427-0.[Epub ahead of print].
10.Fang ZL, Zhang LY, Huang YM, Qing Y, Cao KY, Tian GB(共同通讯作者), Huang X. OprD mutations and inactivation in imipenem-resistantPseudomonas aeruginosa isolates from China. Infect Genet Evol. 2014; 21:124-8.
11.Guo-Bao Tian, Hong-Ning Wang, An-Yun Zhang, Yi Zhang, Wen-Qiao Fan, Chang-Wen Xu, Bo Zeng, Zhong-Bin Guan, Li-Kou Zou. Detection of clinically important β-lactamases in commensal Escherichia coli of human and swine origin in western China. Journal of Medical Microbiology (ISSN: 0022-2615). 2012; 61(Pt 2):233-8.
12.Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Anthony W. Pasculle, John P. Quinn, Hong-Ning Wang, Yohei Doi. Identification of Diverse OXA-40-Group Carbapenemases Including a Novel Variant, OXA-160, from Acinetobacter baumannii in Pennsylvania. Antimicrob Agents Chemother.2010; 55:429-32.
13.Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Hong-Ning Wang, Yohei Doi. PME-1, an Extended-Spectrum β-lactamase Identified inPseudomonas aeruginosa. Antimicrob Agents Chemother. 2011; 55: 2710-2713.
14.Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Yohei Doi. Sequence Type ST405 Escherichia coli Isolate Producing QepA1, CTX-M-15, and RmtB from Detroit, Michigan. Antimicrob Agents Chemother. 2011; 55: 3966-3967.
15.Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Hong-Ning Wang, Yohei Doi. Extended-Spectrum AmpC in Acinetobacter baumannii ADC-56 Confers Resistance to cefepime. Antimicrob Agents Chemother. 2011; 55: 4922-4925.
16.Guo-Bao Tian, Wang Hong-ning, Li-Kou Zou, etc. Detection of clinically important β-lactamases in commensal Escherichia coli of human and swine origin in western China. J Med Microbiol. 2012 61(2):233-8.
17.Guo-Bao Tian, Jemelyn Garcia, Jennifer M. Adams-Haduch, Jennifer P. Evangelista, Raul V. Destura, Hong-Ning Wang, Yohei Doi. CTX-M as the predominant extended-spectrum b-Lactamase among Enterobacteriaceae in Manila, Philippines. J Antimicrob Chemother. 2010; 65: 584-6.
18.Guo-Bao Tian, Jennifer M. Adams-Haduch, Zubair A. Qureshi, Hong-Ning Wang, Yohei Doi. CTX-M-35 Extended-Spectrum b-Lactamase Conferring Ceftazidime Resistance in Citrobacter koserii. International Journal of Antimicrobial Agents. 2010; 35: 412-3.
19.Guo-Bao Tian, Wang Hong-ning, Li-Kou Zou, etc. Detection of CTX-M-15, CTX-M-22, and SHV-2 Extended-Spectrum bata-Lactamases (ESBLs) inEscherichia coli Fecal-Sample Isolates from Pig Farms in China. Foodborne Pathogens and Disease. 2009; 6:297-304.
20.Rongsui Gao,Yongfei Hu,Zhencui Li,Jian Sun,Qingjing Wang,Jingxia Lin,Huiyan Ye,Fei Liu,Swaminath Srinivas, Defeng Li,Baoli Zhu,Ya-Hong Liu,Guo-Bao Tian,Youjun Feng. Dissemination and Mechanism for the MCR-1 Colistin Resistance.PLOS Pathogens.
21.Yi-Yun Liu, Yang Wang, Timothy R Walsh, Ling-Xian Yi, Rong Zhang, James Spencer, Yohei Doi, Guo-bao Tian, Baolei Dong, Xianhui Huang, Lin-Feng Yu, Danxia Gu, Hongwei Ren, Xiaojie Chen, Luchao Lv, Dandan He, Hongwei Zhou, Zisen Liang, Jian-Hua Liu, Jianzhong Shen. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infectious Diseases (ISSN: 1473-3099). 2016; 16(2):161-8. doi: 10.1016/S1473-3099(15)00424-7.
22.Hanna E. Sidjabat, David L. Paterson, Jennifer M. Adams-Haduch, Lindsay Ewan, Anthony W. Pasculle, Carlene A. Muto, Guo-Bao Tian, and Yohei Doi. Molecular Epidemiology of CTX-M-Producing Escherichia coli Isolates at a Tertiary Medical Center in Western Pennsylvania. Antimicrob Agents Chemother 2009; 53: 4733-9.
23.Rebecca I. Waltner-Toews, David L. Paterson, Zubair A. Qureshi, Hanna E. Sidjabat, Jennifer M. Adams-Haduch, Kathleen A. Shutt, Mark Jones, Guo-Bao Tian, Anthony W. Pasculle, and Yohei Doi. Clinical Characteristics of Bloodstream Infections Due to Ampicillin/Sulbactam-Resistant, Non-ESBL-Producing Escherichia coli and the Role of TEM-1 Hyperproduction. Antimicrob Agents Chemother. 2011; 55: 495-501.
24.Tatiana Bogdanovich, Jennifer M. Adams-Haduch, Guo-Bao Tian, Hong M. Nguyen, Eun J. Kwak, Carlene A. Muto, Yohei Doi. Colistin ResistantKlebsiella pneumoniae Carbapenemase (KPC) Producing Klebsiella pneumoniae Belonging to the International Epidemic Clone ST258. Clinical Infectious Diseases. 2011; 53: 373-376.
25.Jennifer M. Adams-Haduch, Ezenwa O. Onuoha, Tatiana Bodganovich, Guo-Bao Tian, Jonas Marschall, Carl Urban, Brad Spellberg, Diane Rhee, Diane Halstead, Anthony W. Pasculle, Yohei Doi. Contemporary Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii in the United States. J Clin Microbiol. 2011;49(11):3849-54.

获奖及荣誉:

1.广州市珠江科技新星
2.高校基本科研业务费青年教师重点培育项目
3.“广东特支计划”百千万工程青年拔尖人才
4.广东省高等院校“千百十工程”第七批校级培养对象
5.所属“抗感染免疫”团队被授予“第四届中国侨界贡献(创新团队)奖”
6.国家科技进步奖二等奖(排名第13)
7.四川省科学技术进步一等奖(排名第16)
8.中山医学院优秀党务工作者
9.中山医学院教学质量奖

学术兼职:

1.中国微生物学会医学微生物学与免疫学专委会第一届青年委员会委员
2.中国防痨协会青年理事会委员
3.全国高等教育医学数字化规划教材《医学微生物学》 编委
4.美国微生物学会(American Society for Microbiology,ASM)会员
5.国家和广东省自然科学基金项目评审专家
6.Clinical Infectious Diseases、Journal of Antimicrobial Chemotherapy 、Antimicrobial Agents and Chemotherapy、Clinical Microbiology and Infection、Oncotarget等杂志审稿专家

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联系我们:sums@mail.sysu.edu.cn

地址:中国广州市中山二路74号中山大学北校区邮政编码:510080