Frontiers in Medical Sciences Lecture Series-290-Insertional mutagenesis of the Zika genome

Author: ZSSOM    UpdateTime: 2017/04/11    Hits: 83

Chairs: Lecture Hall, 4th Floor, Yongsheng Building, North Campus, SYSU

Time: Apr. 14, 15:30

Venue: Lecture Hall, 4th Floor, Yongsheng Building, North Campus, SYSU

About the speaker: Matt is an Associate Professor in the Icahn School of Medicine at Mount Sinai in New York City. His lab studies interactions between viruses and hosts, with an emphasis on how this interface affects both viral tropism and the capacity of hosts to clear infections. This research is focused on the hepatitis C virus (HCV), which is only able to infect human liver cells, and Flaviviruses such as dengue and Zika viruses, which infect a wide range of species and tissues. These viruses also exhibit dramatically different patterns of infections: While Flaviviruses only cause short-term infections, HCV infections typically last for the life of the host. A better understanding of how host factor interactions control suitable targets for infection, and how immune responses influence clearance of these viruses, will be critical for the development of therapeutics and vaccines to treat and prevent infections.

Matt has studied viruses since 1993, when he explored mechanisms of insect virus replication as an undergraduate researcher in the laboratory of John P. Burand at the University of Massachusetts. In graduate school at Columbia University, he studied retroviruses and HCV in the lab of Steve Goff. In 2003, he joined the lab of Charlie Rice at the Rockefeller University as a Charles H. Revson and Kimberly Lawrence-Netter Can Research Discovery Fund Award postdoctoral fellow. There he continued to study the interface between HCV and its host. In 2008, Matt was named a finalist in the postdoctoral category of the New York Academy of Sciences Blavatnik Award for Young Scientists. Matt started his lab in the Department of Microbiology of the Icahn School of Medicine in 2008. Since then, he has been named a Pew Scholar by the Pew Charitable Trusts, a Kavli Fellow by the The Kavli Foundation and the U.S. National Academy of Sciences, a 2014 Ann Palmenberg Junior Investigator by the American Society for Virology, and a Burroughs Wellcome Investigator in the Pathogenesis of Infectious Disease by the Burroughs Wellcome Fund.

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