Xiang Peng

Xiang Peng
  • Email: xiangp@mail.sysu.edu.cn
  • Phone: none.
  • Address: none.
  • Website: none.

     Prof. Andy Peng Xiang graduated from the Department of Biology of the Anhui University in 1994. From 1994 to 1999 he studied for the master and PhD program in West China University of Medical Sciences. After getting his doctorate, he obtained postdoctoral training from 1999 to at the Department of Pathophysiology of Sun Yat-sen University.  From 2001 to 2004 he worked as a research associate at the Department of Human Genetics of University of Chicago/ Howard Hughes Medical Institute (HHMI).

In 2004, he came back to China to establish Center for stem cell biology and tissue engineering and became the full professor in 2007. His research focused on the molecular mechanisms of stem cell self renewal and differentiation. He established the nestin knockout mice model and studied the important role of nestin on neural stem cell survival and tissue regeneration. He also succeeded in deriving ES cells from Apodemus and identified Apodemus ES cells could fully integrate with the inner cell mass of mouse blastocysts to produce viable chimeras despite the considerable evolutionary distance separating these two species, which provided a proof of principle for the feasibility of differentiating pluripotent stem cells into a wide range of cell types—and perhaps even complex tissues—by allowing them to develop in vivo in an evolutionarily divergent host. He is also very interested in the immunomodulatory properties of mesenchymal stem cells and its clinical translation. So far, he has obtained 7 grants from National Natural Science Foundation of China, 3 grants from National Basic Research Program of China (973). Prof. Xiang has published more than 60 papers in peer-reviewed journals, such as Hum Mol Genet, Stem Cells, Biomaterials, Mol Cell, Cell Res, etc.

E-mail: xiangp@mail.sysu.edu.cn

Representative Publications:

1.    Liu J, Li W, Wang Y, Fan W, Li P, Lin W, Yang D, Fang R, Feng M, Hu C, Du Z, Wu G, Xiang AP. ISL1 overexpression in human mesenchymal stem cells promotes vascularization through MCP3. Stem Cells. 2014 Feb 27.doi: 10.1002/stem.1682. [Epub ahead of print] (corresponding author ; IF:7.701)

2. Ke Q, Li L, Cai B, Liu C, Yang Y, Gao Y, Huang W, Yuan X, Wang T, Zhang Q, Harris AL, Tao L, Xiang AP. Connexin 43 is involved in the generation of human-induced pluripotent stem cells. Hum Mol Genet. 2013,22(11):2221-33. (corresponding author ; IF:7.692)

3. Chen F, Cai B, Gao Y, Yuan XF, Cheng FY, Wang T, Jiang MH, Zhou YJ, Lahn BT, Li WQ, Xiang AP. Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells. Biomaterials. 2013, 34(6): 1701-1711. (corresponding author ; IF:7.604)

4. Cheng F, Ke Q, Chen F, Cai B, Gao Y, Ye C, Wang D, Zhang L, Lahn BT, Li W, Xiang AP. Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials. 2012,33(11):3195-204. (corresponding author; IF:7.604)

5. Xu CX, Chen XF, Su PQ, Meng YC, Yu WH, Xiang AP*, Wang YJ. Biocompatibility and osteogenesis of biomimetic Bioglass-Collagen -Phosphatidylserine composite scaffolds for bone tissue engineering. Biomaterials. 2011,32(4):1051-8. (corresponding author ; IF:7.604)

6. Park D, Xiang AP, Mao FF, Zhang L, Di CG, Liu XM, Shao Y, Ma BF, Lee JH, Ha KS, Walton N, Lahn BT,. Nestin is required for the proper self-renewal of neural stem/progenitor cells. Stem Cells.2010,28(12):2162-71. (corresponding author; IF:7.701)

7. Weng JY, Du X, Peng YW, Wang Z, Wu SJ, Lu ZS, Lin W, Xiang AP. Mesenchymal stem cell as salvage treatment for refractory chronic graft-versus-host disease. Bone Marrow Transplant. 2010,45(12):1732-40. (corresponding author ; IF:3.541)

8 .Xiang AP, Mao FF, Li WQ, Park D, Ma BF, Wang T, Vallender TW, Vallender EJ, Zhang L, Lee J, Waters JA, Zhang XM, Yu XB, Li SN &Lahn BT. Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host. Hum Mol Genet. 2008,17 (1):27-37. (corresponding author ; IF:7.692)

Acting Grants:

1. The role and molecular mechanisms of Nestin inMouse embryonic vascular development (31171398, National Natural Science Foundation of China, 650,000 RMB, 2012-2015)

2. The mechanism of CD5+ Regulative B lymphocytes in mesenchymal stem cell treatment of chronic graft-versus-host disease (81270646, National Natural Science Foundation of China, 750,000 RMB, 2013-2016)

3. The study onprimate cells heterogeneous chimeric development (2012CBA01302, National Basic Research Program of China, 12,190,000 RMB, 2012-2016)