个人简介

邓凯博士，中山大学中山医学院教授，博士生导师。现任中山医学院副院长，免疫学教研室主任。本科及硕士毕业于中山大学，博士毕业于美国约翰霍普金斯大学医学院，获分子生物学与遗传学博士学位。在美国霍华德休斯医学研究所(HHMI)从事博士后研究。2015年由中山大学引进回国工作。2015年至今，以通讯作者或第一作者（含共同）在Nature、Immunity、Science Translational Medicine、Cell Host & Microbe、Cell Metabolism、PNAS 等知名杂志发表近30篇学术论文。主持国家科技重大专项（首席）、国家重点研发计划课题、国家自然科学基金面上项目及专项项目（3项）、广东省科技计划基地项目、广东省杰出青年科学基金等科研项目。获聘教育部青年学者（2018年度），广东省“青年珠江学者”（2016年度）。

研究方向

病毒持续性感染的机制
宿主针对病毒感染的免疫应答机理
艾滋病功能性治愈新策略   

学术成果

重要学术成果与贡献：
      病毒的持续性感染是病毒性疾病无法根治，甚至其它疾病（如肿瘤等）发病的主要原因。邓凯博士长期研究病毒在宿主建立和维持持续性感染的机制，及宿主免疫系统的应答规律，并探索如何通过病毒特异性免疫策略治疗持续性病毒感染。以人类免疫缺陷病毒（HIV）、流感病毒和新型冠状病毒为研究对象，系统揭示病毒与免疫系统互作的机制。发表论文被引用超过5000次，H-index 25（Google Scholar）。相关研究成果对推动艾滋病等重大传染病的致病机制研究和临床治疗方案具有重要意义。

教材专著

代表性论文（仅列出通讯作者和第一作者论文，*共同通讯作者，#共同第一作者）：

1. Jinfeng Cai#, Wei Dong#, Peipei Wang, Jiacong Zhao, Xinyu Liang, Zhuoyue Meng, Wei Wang, Jiasheng Zhou, Haixiang Peng, Huixin Wu, Shubin Chen, Jiazhen Chen, Hongbo Gao, Qiankun Wang, Haitao Zhang, Ting Huang, Lilin Wang, Zhanlian Huang, Liang Shan, Zhonghui Tang, Kai Deng. HIV-1 infection converts CD4+ T cells to HLA class II-restricted CD8+ T cells. Science Translational Medicine 2026; 18: eaec4912. (Cover Story, Highlighted in Focus Article)
2. Zhihui Zhang, Haolin Chen*, Beibei Xu, Zeyu Yang, Liyan Li, Zhan Gao, Bo Yang, Xuanli Jin, Hong Liu, Longlong Si*, Kai Deng*, Lixin Liu*, Yongming Chen*. Mucosal-Penetrating Nanovaccine Enhances Mucosal and Systemic Immunity against Respiratory Syncytial Virus Infection. ACS Nano 2026; 20: 9237-9249.
3. Bo Yang, Ao Hu, Tiantian Wang, Xiaolin Chen, Caina Ma, Xinyue Yang, Kai Deng. SARS-CoV-2 infection induces ZBP1-dependent PANoptosis in bystander cells. Proceedings of the National Academy of Sciences 2025; 122: e2500208122.
4. Jinfeng Cai#, Jiasheng Zhou#, Zhuoyue Meng, Ziqi Wu, Jiacong Zhao, Haixiang Peng, Xinyu Liang, Junjian Chen*, Peipei Wang*, Kai Deng*. Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR. Acta Pharmacologica Sinica 2024; 45:1632-1643.
5. Ting Huang#, Jinfeng Cai#, Peipei Wang#, Jiasheng Zhou, Haitao Zhang, Ziqi Wu, Jiacong Zhao, Zhanlian Huang*, Kai Deng*. Ponatinib represses latent HIV-1 by inhibiting AKT-mTOR. Antimicrobial Agents and Chemotherapy 2023; 67: e00067-23.
6. Xiaofei Wang#, Ao Hu#, Xiangyu Chen#, Yixin Zhang#, Fei Yu#, Shuai Yue, Arong Li, Junsong Zhang, Zhiwei Pan, Yang Yang, Yao Lin, Leiqiong Gao, Jing Zhou, Jing Zhao, Fang Li, Yaling Shi, Feng Huang, Xiaofan Yang, Yi Peng, Luoyang Tu, Huan Zhang, Huanying Zheng, Jun He, Hui Zhang, Lifan Xu, Qizhao Huang, Yongqun Zhu*, Kai Deng*, Lilin Ye*. A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD. Signal Transduction and Targeted Therapy 2022; 7: 114.
7. Xiaofei Wang#, Xiangyu Chen#, Jiaxing Tan, Shuai Yue, Runhong Zhou, Yan Xu, Yao Lin, Yang Yang, Yan Zhou, Kai Deng*, Zhiwei Chen*, Lilin Ye*, Yongqun Zhu*. 35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved Spike epitope. Cell Host & Microbe 2022; 30: 887-895.
8. Zilun Li#, Meixiu Peng#, Pin Chen#, Chenshu Liu#, Ao Hu#, Yixin Zhang, Jiangyun Peng, Jiang Liu, Yihui Li, Wenxue Li, Wei Zhu, Dongxian Guan, Yang Zhang, Hongyin Chen, Jiuzhou Li, Dongxiao Fan, Kan Huang, Fen Lin, Zefeng Zhang, Zeling Guo, Hengli Luo, Xi He, Yuanyuan Zhu, Linghua Li, Bingding Huang, Weikang Cai, Lei Gu, Yutong Lu, Kai Deng*, Li Yan*, Sifan Chen*. Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. Cell Metabolism 2022; 34: 424-440.
9. Xiaofan Yang, Ting Huang, Tiantian Wang, Hongbo Gao, Haitao Zhang, Wen Peng, Jiacong Zhao, Shujing Hu, Panpan Lu, Zhongsi Hong, Bo Li, Kai Deng. MAT2A-mediated S-Adenosylmethionine level in CD4+ T cells regulates HIV-1 latent infection. Frontiers in Immunology 2021; 12: 745784.
10. Jinfeng Cai, Hongbo Gao, Jiacong Zhao, Shujing Hu, Xinyu Liang, Yanyan Yang, Zhunaglin Dai, Zhongsi Hong, Kai Deng. Infection with a newly designed dual fluorescent reporter HIV-1 effectively identifies latently infected CD4+ T cells. eLife 2021; 10: e63810.
11. Hongbo Gao#, Ayşe N Ozantürk#, Qiankun Wang, Gray H Harlan, Aaron J Schmitz, Rachel M Presti, Kai Deng*, Liang Shan*. Evaluation of HIV-1 latency reversal and antibody-dependent viral clearance by quantification of singly spliced HIV-1 vpu/ env mRNA. Journal of Virology 2021; 95: e02124-20.
12. Bingfeng Liu#, Yaling Shi#, Wanying Zhang#, Rong Li#, Zhangping He, Xiaofan Yang, Yuejun Pan, Xilong Deng, Mingkai Tan, Lingzhai Zhao, Fan Zou, Yiwen Zhang, Ting Pan, Junsong Zhang, Xu Zhang, Fei Xiao, Fang Li*, Kai Deng*, Hui Zhang*. Recovered COVID-19 patients with recurrent viral RNA exhibit lower levels of anti-RBD antibodies. Cellular and Molecular Immunology 2020; 17: 1098-1100.
13. Xiangyu Chen#, Zhiwei Pan#, Shuai Yue#, Fei Yu#, Junsong Zhang#, Yang Yang, Ren Li, Bingfeng Liu, Xiaofan Yang, Leiqiong Gao, Zhirong Li, Yao Lin, Qizhao Huang, Lifan Xu, Jianfang Tang, Li Hu, Jing Zhao, Pinghuang Liu, Guozhong Zhang*, Yaokai Chen*, Kai Deng*, Lilin Ye*. Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19. Signal Transduction and Targeted Therapy 2020; 5: 1-6.
14. Junsong Zhang#, Jun Liu#, Yaochang Yuan, Feng Huang, Rong Ma, Baohong Luo, Zhihui Xi, Ting Pan, Bingfeng Liu, Yiwen Zhang, Xu Zhang, Yuewen Luo, Jin Wang, Meng Zhao, Gen Lu, Kai Deng*, Hui Zhang*. Two waves of pro-inflammatory factors are released during the influenza A virus (IAV)-driven pulmonary immunopathogenesis. PLoS Pathogens 2020; 16: e1008334
15. Wen Peng#, Zhongsi Hong#, Xi Chen, Hongbo Gao, Zhuanglin Dai, Jiacong Zhao, Wen Liu, Dan Li*, Kai Deng*. Thiostrepton reactivates latent HIV-1 through the p-TEFb and NF-κB pathways mediated by heat shock response. Antimicrobial Agents and Chemotherapy 2020; 64: e02328-19.
16. Fei Yu#, Qijuan Li#, Xi Chen, Jun Liu, Linghua Li, Baojin Li, Bingfeng Liu, Junsong Zhang, Xu Zhang, Zhaoli Liu, Haihua Luo, Xiao-Ping Tang, Weiping Cai, Hui Zhang*, Kai Deng*. X4-tropic latent HIV-1 is enriched in peripheral follicular helper T cells and is correlated with disease progression. Journal of Virology 2020; 94: e01219-19
17. Xiaomin Li, Zhaoli Liu, Qijuan Li, Ronglin Hu, Lu Zhao, Yanyan Yang, Jiacong Zhao, Zhuoqiong Huang, Hongbo Gao, Linghua Li*, Weiping Cai*, Kai Deng*. CD161+ CD4+ T cells harbor clonally expanded replication-competent HIV-1 in antiretroviral therapy-suppressed individuals. mBio 2019; 10: e02121-19.
18. Liang Shan#, Kai Deng#, Hongbo Gao, Sifei Xing, Adam A Capoferri, Christine M Durand, S Alireza Rabi, Gregory M Laird, Michelle Kim, Nina N Hosmane, Hung-Chih Yang, Hao Zhang, Joseph B Margolick, Linghua Li, Weiping Cai, Ruian Ke, Richard A Flavell, Janet D Siliciano, Robert F Siliciano. Transcriptional reprogramming during effector-to-memory transition renders CD4+ T cells permissive for latent HIV-1 infection. Immunity 2017; 47: 766-775.
19. Kai Deng, Mihaela Pertea, Anthony Rongvaux, Leyao Wang, Christine M Durand, Gabriel Ghiaur, Jun Lai, Holly L McHugh, Haiping Hao, Hao Zhang, Joseph B Margolick, Cagan Gurer, Andrew J Murphy, David M Valenzuela, George D Yancopoulos, Steven G Deeks, Till Strowig, Priti Kumar, Janet D Siliciano, Steven L Salzberg, Richard A Flavell*, Liang Shan*, Robert F Siliciano*. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature2015; 517: 381-385.
20. Kai Deng and Robert F Siliciano. HIV: Early treatment may not be early enough. Nature 2014; 512: 35-36.
21. Kai Deng, M Christine Zink, Janice E Clements, Robert F Siliciano. A quantitative measurement of antiviral activity of anti-human immunodeficiency virus type 1 drugs against simian immunodeficiency virus infection: dose-response curve slope strongly influences class-specific inhibitory potential. Journal of Virology 2012; 86:11368-72.
     

科研项目

1. 新发突发与重大传染病防控国家科技重大专项（首席），2025-2028
2. 国家重点研发计划课题，2021-2024
3. 国家自然科学基金新冠专项，2024-2026
4. 国家自然科学基金面上项目，2021-2024
5. 国家自然科学基金面上项目，2017-2020
6. 广东省杰出青年科学基金，2017-2021
7. 广东省科技计划项目，2021-2024
8. 广东省自然科学基金面上项目，2016-2019
9. 中山医学院-中山一院先进医学技术中心项目，2022-2024
10. 中山大学青年教师重点培育项目，2016-2018

获奖及荣誉

1. 2019  广东省科技进步二等奖，第四完成人
2. 2018  国家重大人才工程（青年项目）
3. 2017  广东省“珠江人才计划”引进创新创业团队核心成员
4. 2016  广东省“青年珠江学者”

学术兼职

广东省免疫学会，副理事长
中国免疫学会感染免疫分会，常务委员
中国微生物学会病毒学专业委员会，委员
中国性病艾滋病防治协会，基础研究专业委员会副主任委员