个人简介:

教授,博导,“青年千人”。2006年本科毕业于中山大学生物技术与应用专业,并完成了计算机科学第二专业的学习。2011年于中山大学取得生化与分子生物学博士学位。2011至2016年于美国密歇根大学生态与进化生物学系进行博士后研究。2016年作为中山大学“百人计划”人才引进。2017年入选中组部“千人计划”青年项目。

 

重要学术研究成果与贡献:

生命活动的本质是具有一定随机性的生化反应。这种随机性可以通过各种方式影响生物的功能与进化,并与人类健康具有深入的联系。杨建荣教授从进化基因组与系统生物学的角度,分析生物活动各个层面的随机现象,并发展相关的研究方法和分析工具,揭示随机现象对细胞正常生理功能和相关疾病的潜在重大影响。

 

实验室介绍:

参见实验室主页 https://www.labxing.com/yangjrlab

 

学术论著与教材:

Publications (*: Corresponding author)

  1. JR Yang*, X Chen* (2019) Dosage sensitivity of X-linked genes in human embryonic single cells. BMC Genomics. In press.
  2. JR Yang, CJ Maclean, C Park, H Zhao, and J Zhang* (2017) Intra- and inter-specific variations of gene expression levels in yeast are largely neutral. Molecular Biology and Evolution 34 (9), 2125-2139.
  3. C J Maclean#, BPH Metzger#, JR Yang#, WC Ho, B Moyers, J Zhang* (2017). Deciphering the Genic Basis of Yeast Fitness Variation by Simultaneous Forward and Reverse Genetics. Molecular Biology and Evolution 34 (10), 2486-2502. (#: co-first author)
  4. JR Yang* (2017). Does mRNA structure contain genetic information for regulating co-translational protein folding? Zoological Research 38 (1), 36-43
  5. X Chen, JR Yang, J Zhang* (2015). Nascent RNA folding mitigates transcription-associated mutagenesis. Genome Research 26 (1) 50-59
  6. ZW Guo, C Xie, JR Yang, JH Li, JH Yang*, L Zheng* (2015). MtiBase: a database for decoding microRNA target sites located within CDS and 5’ UTR regions from CLIP-Seq and expression profile datasets. Database 2015: bav102 (9 pages).
  7. J Zhang*, JR Yang (2015). Determinants of the rate of protein sequence evolution. Nature Review Genetics 16 (7):409-420
  8. JR Yang, J Zhang* (2015). Human long noncoding RNAs are substantially less folded than messenger RNAs. Molecular Biology and Evolution 32 (4): 970-977.
  9. JR Yang, X Chen, J Zhang* (2014). Codon-by-codon modulation of translational speed and accuracy via mRNA folding. PLoS Biology 12:e1001910 (14 pages).  HIGHLIGHTED by PLoS Biology Weekly Editors' Picks
  10. JR Yang, S Ruan, J Zhang* (2014). Determinative Developmental cell lineages are robust to cell deaths. PLoS Genetics 10:e1004501 (17 pages).
  11. C Park, X Chen, JR Yang, J Zhang* (2013) Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly. Proc Natl Acad Sci USA. 110:E678-E686.
  12. Q Gong, Y Tao, JR Yang, J Cai, Y Yuan, J Ruan, J Yang, H Liu, W Li, X Lu, SM Zhuang, SM Wang, CI Wu* (2013). Identification of medium-sized genomic deletions with low coverage, mate-paired restricted tags. BMC Genomics 14: 51 (9 pages).
  13. JR Yang, BY Liao, SM Zhuang, J Zhang* (2012) Protein-misinteraction avoidance causes highly expressed proteins to evolve slowly. Proc Natl Acad Sci USA. 109 (14): E831-E840.
  14. W Qian, JR Yang, NM Pearson, CJ Maclean, J Zhang* (2012) Balanced codon usage optimizes eukaryotic translational efficiency. PLoS Genetics 8 (3): e1002603 (18 pages).
  15. Y Zhu, Y Lu, Q Zhang, JJ Liu, TJ Li, JR Yang, C Zeng, SM Zhuang* (2012) MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Research 40 (10): 4615-4625.
  16. JR Yang, SM Zhuang, J Zhang* (2010) Impact of translational error-induced and error-free misfolding on the rate of protein evolution. Molecular Systems Biology 6 (1): 421 (13 pages).
  17. H Zhao, JR Yang, H Xu, J Zhang* (2010) Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dietary switch to bamboo. Molecular Biology and Evolution 27 (12): 2669-2673.
  18. H Su, JR Yang, T Xu, J Huang, L Xi, Y Yuan, SM Zhuang* (2009) MicroRNA-101, Down-regulated in Hepatocellular Carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Research 69 (3): 1135-1142.
  19. T Xu, Y Zhu, QK Wei, Y Yuan, F Zhou, YY Ge, JR Yang, H Su, SM Zhuang* (2008) A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis 29 (11): 2126-2131.

 

 

科研项目研究课题:

  1. 中山大学“百人计划二期”(主持);时间:2016-2021

  2. 国自然面上项目 “利用高通量测序技术检测新生RNA二级结构及检验其对突变率的调节作用”(主持);时间:2017-2020

  3. “千人计划”青年项目(主持);时间:2017-2020

  4. 国自然面上项目 “细胞发育谱系树比对算法的设计与应用”(主持);时间:2019-2022

  5. 国自然重点项目 “质粒介导多粘菌素耐药新机制MCR-1传播、进化和抑制剂研究”(第一参与人);时间:2019-2023

  6. 科技部重点研发项目 “人乳头瘤病毒靶向治疗新技术研发” (骨干);时间:2018-2021