性    别: 男    

导    师: 博士导师,硕士导师

学科专业: 分子生物学,免疫学    

 

个人简介:

    中山大学中山医学院人类病毒学研究所副教授。2003年毕业于中国科学院遗传与发育生物学研究所,获遗传学博士学位。2004年美国伊利诺大学医学院微生物与免疫系做博士后;2009年起在美国农业部Jean Mayer 营养老化研究所营养免疫实验室担任助理研究员;2010年3月中山大学“百人计划”引进。研究领域分子生物学和免疫学。目前研究方向:1)T 细胞发育、分化和免疫功能调节的重要基因功能研究;2) T细胞免疫调节和抗自免疫疾病药物及免疫细胞治疗技术研究;3)细胞发育的表观遗传学机制和环境影响。

学术论著与教材:

1.        Yu B, Qi Y, Liu D, Gao X, Chen H, Bai C, Huang Z. Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm. Fertil Steril. 2013 Oct 7. doi:pii: S0015-0282(13)03050-1. 10.1016/j.fertnstert.2013.09.001. [Epub ahead of print]  (通讯作者)

2.        Chen J, Yang L, Huang Z. The N-terminal 33 amino acid sequence  of Siva-1 is
sufficient for nuclear localization. Brazilian Journal of Medical and Biological Research (已接收)(通讯作者)

3.        Yu B, Chen J, Liu D, Zhou H, Xiao W, Xia X, Huang Z. Cigarette smoking is associated with human semen quality in synergy with functional NRF2 polymorphisms. Biol Reprod. 2013 Jul 5;89(1):5. doi: 10.1095/biolreprod.113.109389.(通讯作者)

4.        Bolan Yu, Zixin Mai, Xuxiang Liu, Zhaofeng Huang. Selective estrogen receptor modulator BC-1 activates antioxidant signaling pathway in vitro via formation of reactive metabolites. Acta Pharmacol Sin. 2013 Mar;34(3):373-9. doi: 10.1038/aps.2012.168. Epub 2013 Jan 21 (通讯作者)

5.        杨丽霞,黄朝峰. RORgt基因启动子的鉴定和特征分析. 免疫学杂志,2013, 29(1):28-32. (通讯作者)

6.        Molano A, Huang Z, Marko MG, Azzi A, Wu D, Wang E, Kelly SL, Merrill AH Jr, Bunnell SC, Meydani SN. Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction. PLoS One. 2012;7(10):e47650. doi: 10.1371/journal.pone.0047650. Epub 2012 Oct 26

7.        Bolan Yu, Huanlan Lin, Lixia Yang, Kang Chen, Haihua Luo , Jianqiao Liu, Xinchen Gao, Xuefeng Xia, Zhaofeng Huang. Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans. J Mol Med (Berl). 2012 Nov;90(11):1333-42. doi: 10.1007/s00109-012-0914-z.  (通讯作者)

8.        Ruiqing Wang, Huimin Xie, Zhaofeng Huang, Jian Ma, Xianfeng Fang, Yan Ding and Zuoming Sun. TCF-1 Regulates Thymocyte Survival via a RORγt-dependent Pathway. J Immunol. 2011,187(11):5964-73

9.        RuiqingWang, Huimin Xie, Zhaofeng Huang, Weirong Shang and Zuoming Sun. Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-xL. Clinical and Developmental Immunology. 2012, Article ID 632837, doi:10.1155/2012/632837

10.    Ruiqing Wang, Huimin Xie, Zhaofeng Huang, Jian Ma, Xianfeng Fang, Yan Ding and Zuoming Sun. Transcription factor network regulating CD4+CD8+ thymocyte survival. Critical Review in Immunology 2011;31(6):447-58.

11.    Huang Z, Wang R, Xie H, Shang W, Manicassamy S and Sun Z. Stabilized β-catenin potentiates peripheral T cell apoptosis by up-regulating Fas.  Journal of Immunology 2008; 180: 6586- 6592.

12.    Manicassamy S, Gupta S, Huang Z, Molkentin J, Shang W and Sun Z. Requirement of Calcineurin A β for the survival of Naïve T cells. Journal of Immunology 2008; 180:106-112

13.    Huang Z, Xie H, Wang R, and Sun Z. Retinoid-related orphan receptor γt is a potential therapeutic target for controlling inflammatory autoimmunity. Expert Opinion on Therapeutic Targets 2007, 11(6):737-743

15.    Xie H, Huang Z, Wang R, and Sun Z. Regulation of thymocyte survival by transcriptional coactivators. Critical reviews in Immunology 2006; 26(6): 475-486

16.    Huang Z, Xie H, Ioannidis V, Held W, Clevers H, Sadim M, and Sun Z. Transcriptional Regulation of CD4 Gene Expression by T Cell Factor-1/β-Catenin Pathway. Journal of Immunology 2006; 176: 4880–4887

17.    Manicassamy S, Gupta S, Huang Z, and Sun Z. Protein Kinase C-θ-Mediated Signals Enhance CD4 T Cell Survival by Up-Regulating Bcl-xL. Journal of Immunology 2006; 176: 6709–6716

18.    Xie H, Huang Z, Sadim SM and Sun Z. Stabilized β-Catenin extends thymocyte survival by up-Regulating Bcl-xL. Journal of Immunology 2005; 175: 7981–7988

 

科研项目研究课题:

1.  b-catenin在Th17细胞分化和自免疫疾病发生中的作用: 黄朝峰
负责人:黄朝峰 参与人: 经费:3.0000 万元 年份:2012
2.  b-Catenin调节T细胞激活后凋亡的分子机制: 黄朝峰
负责人:黄朝峰 参与人: 经费:60.0000 万元 年份:2011