个人简介:

中山大学中山医学院人类病毒学研究所教授,博士生导师。1992-1996和2000-2005年分别就读于武汉大学生命科学学院病毒学专业和微生物学专业,获理学学士和理学博士学位。2005-2010年在美国宾西法尼亚大学和佛罗里达州立大学做博士后研究,研究肿瘤病毒KSHV (Kaposi's sarcoma-associated herpesvirus)感染与复制相关的MAPK信号通路。2010年2月起在美国Sanford-Burnham医学研究所从事自噬反应和肿瘤信号传导研究。发现KSHV感染过程中ORF45介导的ERK-RSK信号持续活化,并阐明其机制和功能,以及发现泛素连接酶RNF5介导的自噬反应调控及其对细菌感染的抵御作用。2011年获批中山大学“百人计划”引进人才,2012年全职加入中山医学院人类病毒学研究所。现从事肿瘤病毒(EBV和KSHV)和自噬反应研究。先后在Trends Biochem Sci.,PLoS Genet., J Virol., J Biol Chem.等杂志以第一或主要作者发表文章20余篇。
 

导    师:博士导师,硕士导师

学术论著与教材:

研究论文
1. Huang L, Yang M, Yuan Y, Li X, Kuang E. Niclosamide inhibits lytic replication of Epstein-Barr virus by disrupting mTOR activation. Antiviral Res. 2017 Feb;138:68-78.
2. Yang M, Huang L, Li X, Kuang E. Chloroquine inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by disrupting mTOR and p38-MAPK activation. Antiviral Res. 2016 Sep;133:223-33. 
3. Long X, Li Y, Yang M, Huang L, Gong W, Kuang E. BZLF1 Attenuates Transmission of Inflammatory Paracrine Senescence in Epstein-Barr Virus-Infected Cells by Downregulating Tumor Necrosis Factor Alpha. J Virol. 2016 Aug 12;90(17):7880-93.
4. Li Y, Long X, Huang L, Yang M, Yuan Y, Wang Y, Delecluse HJ, Kuang E. Epstein-Barr Virus BZLF1-Mediated Downregulation of Proinflammatory Factors Is Essential for Optimal Lytic Viral Replication. J Virol. 2015 Nov 4;90(2):887-903.
5. Li X, Du S, Avey D, Li Y, Zhu F, Kuang E. ORF45-Mediated Prolonged c-Fos Accumulation Accelerates Viral Transcription during the Late Stage of Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2015 Jul;89(13):6895-906.
6. Fu B, Kuang E, Li W, Avey D, Li X, Turpin Z, Valdes A, Brulois K, Myoung J, Zhu F. Activation of p90 ribosomal S6 kinases by ORF45 of Kaposi's sarcoma-associated herpesvirus is critical for optimal production of infectious viruses. J Virol. 2015 Jan;89(1):195-207.
7. Kuang E, Okumura CY, Sheffy-Levin S, Varsano T, Shu VC, Qi J, Niesman IR, Yang HJ, López-Otín C, Yang WY, Reed JC, Broday L, Nizet V, Ronai ZA. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet. 2012;8(10):e1003007.
8. Kuang E, Fu B, Liang Q, Myoung J, Zhu F. Phosphorylation of eukaryotic translation initiation factor 4B (EIF4B) by open reading frame 45/p90 ribosomal S6 kinase (ORF45/RSK) signaling axis facilitates protein translation during Kaposi sarcoma-associated herpesvirus (KSHV) lytic replication. J Biol Chem. 2011 Dec 2;286(48):41171-82.
9. Kuang E, Wu F, Zhu F. Mechanism of sustained activation of ribosomal S6 kinase (RSK) and ERK by kaposi sarcoma-associated herpesvirus ORF45: multiprotein complexes retain active phosphorylated ERK AND RSK and protect them from dephosphorylation. J Biol Chem. 2009 May 15;284(20):13958-68.
10. Kuang E, Tang Q, Maul GG, Zhu F. Activation of p90 ribosomal S6 kinase by ORF45 of Kaposi's sarcoma-associated herpesvirus and its role in viral lytic replication. J Virol. 2008 Feb;82(4):1838-50.
11. Wan Q, Kuang E, Dong W, Zhou S, Xu H, Qi Y, Liu Y. Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. Apoptosis. 2007 Feb;12(2):319-28.
12. Kuang E, Wan Q, Li X, Xu H, Zou T, Qi Y. ER stress triggers apoptosis induced by Nogo-B/ASY overexpression. Exp Cell Res. 2006 Jul 1;312(11):1983-8.
13. Li X, Kuang E, Dai W, Zhou B, Yang F. Efficient inhibition of hepatitis B virus replication by hammerhead ribozymes delivered by hepatitis delta virus. Virus Res. 2005 Dec;114(1-2):126-32.
14. Kuang E, Wan Q, Li X, Xu H, Liu Q, Qi Y. ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP). J Cell Physiol. 2005 Aug;204(2):549-59.


综述
1. Ma Y, Li X, Kuang E. Viral Evasion of Natural Killer Cell Activation. Viruses. 2016 Apr 12;8(4):95. doi: 10.3390/v8040095.
2. Li X, Kuang E. RSK-c-Fos in KSHV lytic progression. Oncotarget. 2015 Sep 22;6(28):24588-9.
3. Kuang E, Qi J, Ronai Z. Emerging roles of E3 ubiquitin ligases in autophagy. Trends Biochem Sci. 2013 Sep;38(9):453-60.

科研项目研究课题:

  • 1.  激活自噬反应治疗KSHV相关肿瘤的实验研究: 况二胜
  • 负责人:况二胜 参与人: 经费:8.0000 万元 年份:2014
  • 2.  ORF45-RSK靶点治疗KSHV诱生肿瘤的实验研究: 况二胜
  • 负责人:况二胜 参与人: 经费:10.0000 万元 年份:2015
  • 3.  调节炎症小体活性的小分子化合物筛选和抗病毒研究: 况二胜
  • 负责人:况二胜 参与人: 经费:20.0000 万元 年份:2014
  • 4.  卡波氏肉瘤相关疱疹病毒诱生肿瘤对MEK抑制剂和mTOR抑制剂耐药的机制研究 : 况二胜
  • 负责人:况二胜 参与人: 经费:60.0000 万元 年份:2013
  • 5.  RNF5在卡波氏肉瘤相关疱疹病毒感染与致病中的作用和机制: 况二胜
  • 负责人:况二胜 参与人: 经费:70.0000 万元 年份:2013
  • 6.  MAPK活化和自噬反应功能缺陷型KSHV重组病毒研究 : 况二胜
  • 负责人:况二胜 参与人: 经费:4.0000 万元 年份:2013