性    别: 男    

导    师: 硕士导师学科专业: 法医物证学    

 


个人简介:
 
       2005年6月本科毕业于中山大学中山医学院法医学系,获“中山大学优秀毕业生”称号,并获免试研究生资格,于2005年9月在中山大学中山医学院免试攻读研究生, 从事脑卒中离子通道学研究,2010年6月毕业, 获医学博士学位。2010年7月留校任教, 在中山大学中山医学院法医学系任讲师, 2013年获评硕士研究生导师,后晋升为副教授,在国家级司法鉴定机构“中山大学法医鉴定中心”任法医物证鉴定专家。目前研究兴趣在法医遗传学和分子生物学。参加工作以来,已在Cardiovascular research,International journal of legal medicine等国际核心杂志发表SCI论文10篇,其中通讯作者1篇(IF6.6),第一作者或共同第一作者5篇(其中IF>5的有3篇),主持国家自然科学基金等科研项目5项,获2013年中山大学中山医学院青年学术奖一等奖,2013年教育部自然科学二等奖和2014年度中华医学科技奖二等奖(第6完成人)。

 

 

学术论著与教材:
 
Acting Grants:

1.2014~2017 Role of ClC-3 in hydrogen peroxide-induced mitophagy in artery smooth muscle cells. National Natural Science Foundation of China, 230,000 RMB, Principal Investigator (Number: 81300106)

2.2013~2017 Mechanism of ClC-3 in regulating hypertensive cerebrovascular remodeling. Provincial Natural Science Fund Project of Guangdong, 30,000 RMB, Principal Investigator (Number: S2012040006519)

3. 2012~2015 Mechanism of ClC-3 chloride channels in regulating hypertensive cardiac hypertrophy induced by Angiotension-Ⅱ in mice. Fundamental Research Funds for the Central Universities, 150,000 RMB, Principal Investigator (Number: 11YKPY06)

 

 

Representative Publications:

1、Wang, Xiao-Guang#,Tao, Jing,Ma, Ming-Ming,Tang, Yong-Bo,Zhou, Jia-Guo,Guan, Yong-Yuan*,Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells,Cardiovasc Res,,2013,98(3):469-478(Impact factor:6.02)

2、Fang Liu,Qing-Hua Cao,De-Jian Lu,Bin Luo,Xiao-Fang Lu,Rong-Cheng Luo,Xiao-Guang Wang*,TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-βsignaling,Oncotarget,2015,Epub ahead of print. (Impact factor:6.61)

3、Liu, Yu-Jie#,Wang, Xiao-Guang#,Tang, Yong-Bo,Chen, Jing-Hui,Lv, Xiao-Fei,Zhou, Jia-Guo,Guan,Yong-Yuan*,Simvastatin Ameliorates Rat Cerebrovascular Remodeling During Hypertension via Inhibition of Volume-Regulated Chloride Channel,HYPERTENSION,2010,56(3):445-452(Impact factor:6.93)

4、Zeng, Jia-Wei#, Wang, Xiao-Guang#,Ma, Ming-Ming,Lv, Xiao-Fei,Liu, Jie,Zhou, Jia-Guo,Guan,Yong-Yuan*,Integrin beta3 mediates cerebrovascular remodelling through Src/ClC-3 volume-regulated Cl- channel signalling pathway.,Br J Pharmacol,,2014,171(13):3158-3170(Impact factor:5.04)

5、Xue, L.#,Li, Z. D.,Chen, Z. X.,Wang, X. G.,Shi, Y. W.,Zhao, H.*.Fear response failed to return in AAB extinction paradigm accompanied with increased NR2B and GluR1 per845 in hippocampalCA1.,Neuroscience,2014,260:1-11(Impact factor:3.02)

6、Li, Shi-Yang#,Wang, Xiao-Guang#,Ma, Ming-Ming,Liu, Yun,Du, Yan-Hua,Lv, Xiao-Fei,Zhou,Jia-Guo,Tang, Yong-Bo*,Guan, Yong-Yuan*,Ginsenoside-Rd potentiates apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through the mitochondrial pathway,Apoptosis,2012,17(2):113-120(Impact factor:4.32)

7、Hao, Li#,Wang, Xiaoguang,Cheng, Jian-Ding,You, Sheng-Zhong,Ma, Su-Hua,Zhong, Xia,Quan, Li*,Luo,Bin*,The up-regulation of endothelin-1 and down-regulation of miRNA-125a-5p, -155, and -199a/b-3p in human atherosclerotic coronary artery.,Cardiovascular Pathology,2014,23(4):217-223(Impact factor:2.26)

8、Huang, Jinglu#,Wang, Xiaoguang,Hao, Bo,Chen, Yijiu,Liu, Hong,Quan, Li,Tang, Dawei,Sheng,Lihui,Li, Ming,Huang, Erwen,Liu, Chao,Luo, Bin*,Genetic Variants in KCNE1, KCNQ1, and NOS1AP in Sudden Unexplained Death During Daily Activities in Chinese Han Population.,Journal of Forensic Sciences,2015,Epub ahead of print(Impact factor:1.23)

9、Tong ZT, Cai MY, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F,Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D.EZH2 supports nasopharyngeal carcinoma aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene. 2012 Feb;31:583-94(Impact factor:7.36)

10、Liu QL, Zhao H, Chen JD, Wang XG , Lu DJ, Quan L*. Development and population study of the 12 X-STR loci multiplexes PCR systems. International Journal of legal medicine.2012 Jul; 126(4):665-70(Impact factor:2.68)