性    别: 女    

导    师: 硕士导师

学科专业: 药理学
 


个人简介:
受教育经历:

2005/09-2010/06,中山大学,中山医学院药理系,博士;

2000/09-2005/06,首都医科大学,临床医学系,本科生。

研究工作经历:

2013/01-至今,中山大学,中山医学院药理系,副教授;

2010/07-2012/12,中山大学,中山医学院药理系,讲师。 

 

重要学术研究成果与贡献:

研究领域为肿瘤药理,主要研究方向为肿瘤治疗新策略,包括恶性胶质瘤诱导分化治疗和溶瘤病毒疗法。近五年共发表SCI 论文28 篇(第一作者或共同第一作者9 篇,通讯作者4篇),核心期刊1 篇, 国内其他期刊2 篇(第一作者),2次参编英文脑肿瘤专著,,其中:作为共同通讯作者在细胞生物学权威杂志Cell子刊Cell Reports(中科院一区)上发表了关于逆转恶性胶质瘤的Warburg效应促进胶质瘤细胞分化的研究成果;作为第一作者在药理学权威期刊Molecular Pharmacology(中科院二区)和Vascular Pharmacology(中科院二区)上发表2篇文章,报道了肿瘤血管生成抑制疗法较为重要的研究成果;在Molecular Pharmacology(中科院二区)和Journal of Cellular Biochemistry(中科院二区)上发表2篇文章,报道了恶性胶质瘤诱导分化疗法的信号通路调控机制。作为项目负责人获得2项国家自然科学基金项目、1项广东省科技厅应用型科研专项重点项目和3 项广东省自然科学基金项目资助。 

 

学术论著与教材:

1. 5篇代表性论文:*为通讯作者,#为第一作者或共同第一作者

(1)     Fan Xing, Yizhao Luan, Jing Cai, Sihan Wu, Jialuo Mai, Jiayu Gu, Haipeng Zhang, Kai Li, Yuan Lin, Xiao Xiao, Jiankai Liang, Yuan Li, Wenli Chen, Yaqian Tan,Longxiang Sheng, Bingzheng Lu, Wanjun Lu, Mingshi Gao,Pengxin Qiu, Xingwen Su,Wei Yin, Jun Hu, Zhongping Chen, Ke Sai , Jing Wang, Furong Chen, Yinsheng Chen, Shida Zhu, Dongbing Liu, Shiyuan Cheng, Zhi Xie*, Wenbo Zhu*, Guangmei Yan*. Anti-Warburg Effect Elicited by cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes. Cell Reports, 2016, accepted. (中科院一区)

(2)     Wenbo Zhu#, Yanqiu Ou, Yan Li,Ru Xiao, Minfeng Shu, Yuehan Zhou, Jun Xie, Songmin He, Pengxin Qiu,and Guangmei Yan*. A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma cells via Down-Regulation of the Nuclear Factor-κB Pathway. Molecular Pharmacology, 2009, 75:1-8.(中科院二区)

(3)     Wenbo Zhu , Songmin He , Yan Li , Pengxin Qiu, Minfeng Shu, Yanqiu Ou, Yuehan Zhou, Tiandong Leng, Jun Xie, Xiaoke Zheng, Dong Xu, Xingwu Su, Guangmei Yan. Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells. Vascular Pharmacology, 2010, 52: 46-54. (中科院二区)

(4)     Songmin He#, Wenbo Zhu#, Yuxi Zhou, Yijun Huang, Yanqiu Ou, Yan Li, Guangmei Yan*. Transcriptional and post-transcriptional downregulation of cyclin D1 contributes to C6 glioma cell differentiation induced by Forskolin. Journal of Cellular Biochemistry, 2011, 112:2241-2249. (中科院二区)

(5)     Xiaoqiang Sun #*, Xiaoke Zheng#, Jiajun Zhang, Tianshou Zhou, Guangmei Yan, Wenbo Zhu*. Mathematical modeling reveals a critical role for cyclin D1 dynamics in phenotype switching during glioma differentiation. FEBS Letters, 2015, 589: 2304-2311. (中科院三区)

2. 专著(胶质瘤专著章节):

(1)     Wenbo Zhu and Guangmei Yan (2011). The Molecular Mechanism for Differentiation Therapy of Malignant Glioma, Brain Tumors - Current and Emerging Therapeutic Strategies, Ana L. Abujamra (Ed.), ISBN: 978-953-307-588-4, InTech.

(2)     Sihan Wu, Wenbo Zhu and Guangmei Yan (2012). Evolvement of microRNAs as therapeutic targets for malignant gliomas- Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications, Terry Lichtor (Ed.), ISBN 980-953-307-523-0, InTech. 

 

学术兼职:

1. 2012.5.22-至今,任职广东省药理学会神经药理专业委员会委员

2. 2016.11.5-至今,任职广东省抗癌协会专业委员会委员