赵萌 博士中山大学中山医学院教授、博士生导师、中组部千人计划青年项目国家优秀青年科学基金获得者。2002年毕业于山东大学获得医学学士学位;2009年毕业于中科院上海生命科学研究院/上海交通大学医学院健康科学研究所师从上海交通大学医学院陈国强院士获得生物化学与分子生物学博士,2010年起在美国Stowers Institute for Medical Research从事博士后研究,师从著名华人干细胞专家Linheng Li教授;2016年以中山大学百人计划急需人才引进回国,在中山大学任职至今。

主要从事造血干细胞骨髓微环境以及骨髓间充质干细胞的基础转化研究,在NatureNature MedicineCell Stem CellBloodThe Journal of Experimental Medicine等学术期刊发表论文20 余篇、引用700余次。主要学术贡献:阐明了骨髓微环境对造血干细胞静息期维持的细胞和分子机制(JEM 2018 Nat Med 2014);表观遗传学对造血干细胞静息期维持和能量代谢的调控机制(Cell Stem Cell 2018Cell Stem Cell 2016Nature 2013);骨髓微环境对造血干细胞化疗后损伤修复的调控作用(Nat Med 2014Blood 2012)。先后获得基金委面上项目、重大研究计划(培育项目)、国家优秀青年科学基金项目、科技部干细胞重点专项课题、广东省珠江人才创新团队支持、中山大学青年教师重点培育等项目资助。

 

获得基金:

2011-2013        国家自然科学基金青年项目 (NSFC, 81000214)C/EBPα磷酸化与泛素化降解之间的关系及其在白血病细胞凋亡中的作用,主持,结题,主持

2017-2020       国家自然科学基金 面上项目(NSFC, 81670101),骨髓微环境中的WNT信号通路促进造血干细胞再生修复的研究,主持,在研,主持

2017-2020       中山大学重点培育计划,在研,主持

2017-2021        科技部重点研发计划,课题负责人(2017YFA0103403),中胚层来源组织干细胞的微环境调控及制备策略,在研,课题负责人

2017-2022        广东省珠江人才计划青年英才团队,iPS细胞源性组织构建及其治疗重大疾病的新技术研发,核心成员,在研,核心成员

2018-2020      国家自然科学重大研究计划,91749106, TGFβ-SHP-1信号通路调控造血干细胞衰老的分子机制研究,在研,主持;

2018-2022        科技部重点研发计划,课题负责人(2018YFA0107200),间充质干细胞亚群的功能鉴定、分离制备与疗效评估,在研,骨干

2019-2021        国家自然科学基金优秀青年科学基金,造血干细胞骨髓微环境,81822001在研,主持

发表论文:

  1. Qian, P., De Kumar, B., He, X. C., Nolte, C., Gogol, M., Ahn, Y., Chen, S., Li, Z., Xu, H., Perry, J. M., Hu, D., Tao, F., Zhao, M., Han, Y., Hall, K., Peak, A., Paulson, A., Zhao, C., Venkatraman, A., Box, A., Perera, A., Haug, J. S., Parmely, T., Li, H., Krumlauf, R., and Li, L. (2018) Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis. Cell Stem Cell 22, 740-754 e747影响因子22.39
  2. Kang, X., Cui, C., Wang, C., Wu, G., Chen, H., Lu, Z., Chen, X., Wang, L., Huang, J., Geng, H., Zhao, M., Chen, Z., Muschen, M., Wang, H. Y., and Zhang, C. C. (2018) CAMKs support development of acute myeloid leukemia. J Hematol Oncol 11, 30影响因子6.3
  3. Jiang, L., Han, X., Wang, J., Wang, C., Sun, X., Xie, J., Wu, G., Phan, H., Liu, Z., Zhang, C.*, Zhao, M.*, and Kang, X*. (2018) SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-beta signaling. The Journal of experimental medicine *通讯作者,影响因子12
  4. Qin W, Zheng Y, Qian BZ*, Zhao M*. Prostate cancer stem cells and nanotechnology: A focus on wnt signaling. Frontiers in pharmacology, 2017, 8: 153. *通讯作者,影响因子4.8
  5. Wang J, Zheng Y, Zhao M*. Exosome-Based Cancer Therapy: Implication for Targeting Cancer Stem Cells. Frontiers in pharmacology. 2016;7:533. *通讯作者,影响因子4.8
  6. Zhao, M., Li, L. (2016) Dissecting the bone marrow hematopoietic stem cell niches. Cell Res. 26: 975-976影响因子14.82
  7. Qian, P., He, X. C., Paulson, A., Li, Z., Tao, F., Perry, J. M., Guo, F., Zhao, M., Zhi, L., Venkatraman, A., Haug, J. S., Parmely, T., Li, H., Dobrowsky, R. T., Ding, W. X., Kono, T., Ferguson-Smith, A. C., Li, L. 2016 The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell stem cell 18, 214-228. 影响因子22.39
  8. Zhao, M., Li, L. 2015 Regulation of hematopoietic stem cells in the niche. Science China Life Sciences 58, 1209-1215. 影响因子2.30
  9. Zhao, M., Li, L. 2015. Osteoblast ablation burns out functional stem cells. Blood. 2015;125(17):2590-2591. 影响因子11.84
  10. Zhao, M., Perry, J.M., Marshall, H., Venkatraman, A., Qian, P., He, X.C., Ahamed, J., and Li, L. 2014. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med 20, 1321-1326. (Cover article). Featured in: Day, R. B. & Link, D. C. 2014 Megakaryocytes in the hematopoietic stem cell niche. Nat Med 20, 1233-1234. 影响因子30.36
  11. Venkatraman, A., He, X.C., Thorvaldsen, J.L., Sugimura, R., Perry, J.M., Tao, F., Zhao, M., Christenson, M.K., Sanchez, R., Yu, J.Y., et al. 2013. Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Nature 500:345-349. 影响因子38.12
  12. Zhao, M., Ross, J.T., Itkin, T., Perry, J.M., Venkatraman, A., Haug, J.S., Hembree, M.J., Deng, C.X., Lapidot, T., He, X.C., et al. 2012. FGF signaling facilitates postinjury recovery of mouse hematopoietic system. Blood 120:1831-1842. 影响因子11.84
  13. Xia, L., Wang, T.D., Shen, S.M., Zhao, M., Sun, H., He, Y., Xie, L., Wu, Z.X., Han, S.F., Wang, L.S., et al. 2013. Phosphoproteomics study on the activated PKCdelta-induced cell death. J Proteome Res 12:4280-4301. 影响因子4.17
  14. Wu, Z.X., Zhao, M. (co-first author), Xia, L., Yu, Y., Shen, S.M., Han, S.F., Li, H., Wang, T.D., Chen, G.Q., and Wang, L.S. 2013. PKCdelta enhances C/EBPalpha degradation via inducing its phosphorylation and cytoplasmic translocation. Biochem Biophys Res Commun 433:220-225. 影响因子2.37
  15. Zhao, M., Xia, L., and Chen, G.Q. 2012. Protein kinase cdelta in apoptosis: a brief overview. Arch Immunol Ther Exp (Warsz) 60:361-372. 影响因子2.46
  16. Zhao, X.Y., Zhao, K.W., Jiang, Y., Zhao, M., and Chen, G.Q. 2011. Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells. J Biol Chem 286:36808-36819. 影响因子4.26
  17. Gu, Z.M., Liu, C.X., Wu, S.F., Zhao, M., Xu, H.Z., Liu, W., Zhou, H.C., Chen, G.Q., and Wu, Y.L. 2011. PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells. FEBS Lett 585:375-380. 影响因子3.52
  18. Duan, X.F., Wu, Y.L., Xu, H.Z., Zhao, M., Zhuang, H.Y., Wang, X.D., Yan, H., and Chen, G.Q. 2010. Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes. Chem Biol Interact 183:222-230. 影响因子2.62
  19. Zhao, M., Duan, X.F., Zhao, X.Y., Zhang, B., Lu, Y., Liu, W., Cheng, J.K., and Chen, G.Q. 2009. Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells. PLoS One 4:e6552. 影响因子3.06
  20. Zhao, M., Duan, X.F., Wen, D.H., and Chen, G.Q. 2009. PU.1, a novel caspase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells. Biochem Biophys Res Commun 382:508-513. 影响因子2.37
  21. Zhang, R., Wu, Y., Zhao, M., Liu, C., Zhou, L., Shen, S., Liao, S., Yang, K., Li, Q., and Wan, H. 2009. Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 297:L631-640. 影响因子4.72
  22. Gao, F.H., Wu, Y.L., Zhao, M., Liu, C.X., Wang, L.S., and Chen, G.Q. 2009. Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Exp Cell Res 315:3250-3258. 影响因子3.38
  23. Chen, S., Han, Y.H., Zheng, Y., Zhao, M., Yan, H., Zhao, Q., Chen, G.Q., and Li, D. 2009. NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells. Leuk Res 33:1108-1113. 影响因子2.61

论著:

  1. Venkatraman, A., Zhao, M., and Li, L. 2014. “The hematopoietic stem cell niche”, Biomaterials and Regenerative Medicine, Cambridge University Press, ISBN: 9781107012097
  1. He X. C., Li Z., Sugimura. R., Ross J., Zhao, M., and Li L. 2014. “Homing and Migration Assays of Hematopoietic Stem/Progenitor Cells”, Hematopoietic Stem Cell Protocols, Springer
  1. Zhou.B.O, Li L, Zhao, M*. 2017 “The evolvement of hematopoietic stem cell niches”,   Advance in Stem Cells and their niche. (*通讯作者)  ELSEVIER