性    别: 男    

导    师: 博士导师

学科专业: 干细胞与再生医学

   
个人简介:

      现任中山大学中山医学院教授、博士生导师,广东省青年珠江学者、中山大学“百人计划”二期引进人才。张宏波教授2010 年毕业于上海交通大学获理学硕士学位,随后赴瑞士苏黎世大学和洛桑瑞士联邦理工大学师从代谢领域权威Johan Auwerx教授攻读博士学位。其研究工作第一次揭示了干细胞衰老的线粒体失衡机制,提出线粒体应激(Mitochondrial stress)在调节骨骼肌干细胞衰老中的重要作用,并发现了NAD+依赖的抑制骨骼肌营养不良疾病和干细胞衰老的小分子营养干预方法。相关成果发表于 Science、Science Translational Medicine、Nature Reviews Endocrinology、Kidney International 等期刊,并获第一发明人国际专利2项。
      实验室综合运用生物信息学、生化与分子生物学、细胞生物学等手段研究能量代谢,尤其是线粒体功能对骨骼肌干细胞等成体干细胞功能维持和衰老的调节。现阶段主要研究方向如下:
      1. 成体干细胞衰老机制研究 
      2. 能量代谢和线粒体对成体干细胞功能和命运决定的影响 
      3. 骨骼肌稳态对系统能量代谢的调节

 

学术论著与教材:


近期论文:

1            Wang, S., Zhang, B., Addicks, G. C., Zhang, H., Keir, J. M.*, & Zhang, H*. Muscle Stem Cell Immunostaining. Current Protocols in Mouse Biology, 8(3), e47. (2018) (*, corresponding authors)

 

2            Zhang, H., Menzies, K. J., & Auwerx, J. The role of mitochondria in stem cell fate and aging. Development, 145(8). (2018)

 

3            Addicks, G. C., Marshall, P., Jasmin, B. J., Renaud, J. M., Zhang, H. *, & Menzies, K. J. * Critical Assessment of the mdx Mouse with Ex Vivo Eccentric Contraction of the Diaphragm Muscle. Current Protocols in Mouse Biology, 8(3), e49. (2018) (*, corresponding authors)

 

4            Li, H., Wang, X., Rukina, D., Huang, Q., Lin, T., Sorrentino, V., Zhang, H., Bou Sleiman, M., Arends, D., McDaid, A., Luan, P., Ziari, N., Velazquez-Villegas, L. A., Gariani, K., Kutalik, Z., Schoonjans, K., Radcliffe, R. A., Prins, P., Morgenthaler, S., Williams, R. W., & Auwerx, J. An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function. Cell Systems, 6(1), 90-102 e104 (2018).

 

5            Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D'Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., Counts, S. E., & Auwerx, J. Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity. Nature, 552(7684), 187-193. (2017)

 

6        Gariani, K., Ryu, D., Menzies, K. J., Yi, H. S., Stein, S., Zhang, H., Perino, A., Lemos, V., Katsyuba, E., Jha, P., Vijgen, S., Rubbia-Brandt, L., Kim, Y. K., Kim, J. T., Kim, K. S., Shong, M., Schoonjans, K., Auwerx, J. Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. Journal of Hepatology, 66, 131-142, (2017).

 

7       Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D'Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., Schoonjans, K., Menzies, K. J. & Auwerx, J. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352, 1436-1443, (2016).

         

           Be selected for perspective in Science, 352, 1396 (2016); highlighted in Nature Reviews Molecular Cell Biology, 17, 331 (2016),  Cell Research, 16, 971 (2016) and recommended in F1000 prime.

 

8        Ryu, D.#, Zhang, H.#, Ropelle, E. R.#, Mazala, D. G., Mouchiroud, L., Sorrentino, V., Campbell, M. D., Ali, A. S., Bellemin, S., Lyer, S., Gariani, K., Sauve, A. A., Canto, C., Conley, K. E., Walter, L., Lovering, R. M., Chin, E. R., Marcinek, D. J. Menzies, K. J., & Auwerx, J. NAD+ repletion improves muscular dystrophy by countering increased levels of PARylation. Science Translational Medicine, 361, 361ra139 (2016). (#, equal contribution).

 

9     Menzies, K. J.#, Zhang, H.#, Katsyuba, E.# & Auwerx, J. Protein acetylation in metabolism - metabolites and cofactors. Nature Reviews Endocrinology, 12, 43-60, (2016). (#, equal contribution)

 

10      Rabhi, N., Denechaud, P. D., Gromada, X., Hannou, S. A., Zhang, H., Rashid, T., Salas, E., Durand, E., Sand, O., Bonnefond, A., Yengo, L., Chavey, C., Bonner, C., Kerr-Conte, J., Abderrahmani, A., Auwerx, J., Fajas, L., Froguel, P. & Annicotte, J. S. KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell Reports, 165, 1051-1061, (2016).

 

11     Gariani, K., Menzies, K. J., Ryu, D., Wegner, C. J., Wang, X., Ropelle, E. R., Moullan, N., Zhang, H., Perino, A., Lemos, V., Kim, B., Park, Y. K., Piersigilli, A., Pham, T. X., Yang, Y., Siah Ku, C., Koo, S. I., Fomitchova, A., Canto, C., Schoonjans, K., Sauve, A. A., Lee, J. Y. & Auwerx, J. Eliciting the mitochondrial unfolded protein response via NAD repletion reverses fatty liver disease. Hepatology, 63, 1190-1204, (2015).

 

12     Spichtig, D.#, Zhang, H.#, Mohebbi, N., Pavik, I., Petzold, K., Stange, G., Saleh, L., Edenhofer, I., Segerer, S., Biber, J., Jaeger, P., Serra, A. L. & Wagner, C. A. Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease. Kidney International, 85, 1340-1350, (2014). (#, equal contribution).

 

           Chosen for perspective in Kidney international, 85, 1260-1262 and recommended in F1000 prime.

 

13      Ryu, D., Jo, Y. S., Lo Sasso, G., Stein, S., Zhang, H., Perino, A., Lee, J. U., Zeviani, M., Romand, R., Hottiger, M. O., Schoonjans, K. & Auwerx, J. A SIRT7-dependent acetylation switch of GABPbeta1 controls mitochondrial function. Cell Metabolism, 20, 856-869, (2014).

 

14     Pirinen, E., Canto, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., Williams, E. G., Mouchiroud, L., Moullan, N., Hagberg, C., Li, W., Timmers, S., Imhof, R., Verbeek, J., Pujol, A., van Loon, B., Viscomi, C., Zeviani, M., Schrauwen, P., Sauve, A. A., Schoonjans, K. & Auwerx, J. Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle. Cell Metabolism, 19, 1034-1041, (2014).

 

专利:

1   Zhang, H., Menzies, K. J., Auwerx, J. Ryu, D. Agents and methods using thereof for the prevention and treatment of stem cells senescence. International patent, WO2017042198, 2017. 

2   Zhang, H., Menzies, K. J., Auwerx, J. Ryu, D. Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders. International patent, WO2017042196, 2017

 

获奖及荣誉:

2018  广东省青年珠江学者
2016   瑞士青年科学家奖(Swiss Young Investigator Award
2016   The Lausanne Integrative Metabolism and Nutrition Alliance travel grant;
2014   CARIGEST  干细胞研究奖(fellowship award for stem cell research

 

其 他:

实验室长期欢迎有志于生命科学和基础医学,尤其是能量代谢和干细胞衰老研究的硕博士研究生、博士后和专职科研人员加盟。
现阶段拟招聘专职科研人员或博后2名:
 


岗位招聘条件:

1) 具有生物学,生物信息学,统计学或计算机科学等博士学位或已通过博士学位答辩; 
2) 具有良好的生物信息学基础,或具有扎实的生物化学,分子生物学实验基础;
3) 已取得一定的研究成果,在本学科重要学术刊物上以第一作者发表过SCI论文; 
4) 热爱研究工作,踏实严谨,有良好的团队协作精神;
5) 英语熟练,有良好的撰写学术论文的能力。
 


相关待遇:

依据中山大学相关文件提供有竞争力的薪酬待遇,并提供实验室内奖励和激励机制。中山大学现阶段博士后和专职科研人员待遇如下:
1.特聘研究员:38周岁以下,博士毕业,有4项及以上代表性学术成果(中科院分区表二区期刊以上论文,如文章优秀,项数可适当放宽),有国家级基金项目申请及主持或参与经历。工资参照中山大学专职科研岗工资标准,年薪30-36万元(税前)。 
2. 特聘副研究员: 38周岁以下,博士毕业,有2项及以上代表性学术成果(中科院分区表二区期刊以上论文)。工资参照中山大学专职科研岗工资标准,年薪18-25万元(税前)。 
3. 博士后:要求35周岁以下,海内外知名高校或研究机构的博士毕业生。工资待遇税前 16万元以上。按照学校政策享受住房、子女入学及其他相关待遇,享受公费医疗,学校为其缴纳养老保险和住房公积金。
 


应聘材料:

有意者请将详细个人简历(包括学习工作经历、主要研究方向、代表论文论著、所获荣誉获奖励等)发送至邮箱 zhanghongbo@mail.sysu.edu.cn,主题请注明“岗位应聘”。热忱欢迎国内外优秀博士毕业生加盟!