性    别: 女    

导    师: 硕士导师

学科专业: 药理学

 

 

个人简介:
受教育经历:

2007/09-2012/06,中山大学,中山医学院,药理学博士;

2002/09-2007/06,中山大学,中山医学院,临床医学本科。

研究工作经历:

2016/01-至今,中山大学,中山医学院,副教授;

2012/07-2015/12,中山大学,中山医学院,讲师。 

重要学术研究成果与贡献:

研究领域为心血管药理学,主要研究方向为Cl-通道与心血管疾病的关系研究,重点研究Cl-通道与高血压等心血管疾病发生发展的关系,从Cl-通道角度探讨心血管疾病的共同发病机制,寻找心血管疾病的干预靶标,发展新型抗心血管疾病药物。相关成果发表在心血管药理研究领域Hypertension、Br J Pharmacol.、J Mol Cell Cardiol.、Cardiovasc Res. 等高水平杂志上。近五年发表SCI论文19篇,其中通讯作者或共同通讯作者SCI论文2篇,第一作者SCI论文2篇,共同第一作者SCI 论文7篇。作为项目负责人获得1项国家自然科学基金项目、1项广东省自然科学基金自由申请项目、1项广东省卫生厅青年项目、1项高校基本业务费青年教师重点培育、1项高校基本业务费青年教师培育项目、1项广州市科技计划项目科学研究专项(一般项目)。 

获奖情况:

1、中国药理学会青年药理学家奖,2017

2、Cl-通道对脑血管重构的作用及其机理研究,广东省科学技术奖一等奖,2016,第七完成人

3、Cl-通道对脑血管重构的作用及其机理研究,教育部自然科学奖二等奖,2013,第七完成人

代表性论文(或论著)

1TMEM16A contributes to endothelial dysfunction by facilitating Nox2 NADPH oxidase-derived reactive oxygen species generation in hypertension. Ming-Ming Ma#*, Min Gao#, Kai-Min Guo#, Mi Wang#, Xiang-Yu Li, Xue-Lin Zeng, Lu Sun, Xiao-Fei Lv, Yan-Hua Du, Guan-Lei Wang, Jia-Guo Zhou, Yong-Yuan Guan*. Hypertension. 2017;69(5):892-901. (JCR一区,IF=6.823, 第一及通讯作者)

2Threonine532 phosphorylation in ClC-3 channels is required for angiotensin II-induced Cl- current and migration in cultured vascular smooth muscle cells. Ming-Ming Ma#, Cai-Xia Lin#, Can-Zhao Liu#, Min Gao, Lu Sun, Yong-Bo Tang, Jia-Guo Zhou, Guan-Lei Wang*, Yong-Yuan Guan*. Br J Pharmacol. 2016;173(3):529-44. (JCR一区,IF=5.491, 第一作者)

3Simvastatin attenuated cerebrovascular cell proliferation in the development of hypertension through Rho/Rho-kinase pathway. Ming-Ming Ma#, Shi-Yang Li#, Mi Wang, Yong-Yuan Guan*. J Cardiovasc Pharmacol. 2012;59(6):576-82. (SCI收录,IF=2.383, 第一作者)

4Transmembrane member 16A participates in hydrogen peroxide-induced apoptosis by facilitating mitochondria-dependent pathway in vascular smooth muscle cells. Jia-Wei Zeng#, Bao-Yi Chen#, Xiao-Fei Lv#, Lu Sun, Xue-Lin Zeng, Hua-Qing Zheng, Yan-Hua Du, Guan-Lei Wang, Ming-Ming Ma*, Yong-Yuan Guan*. Br J Pharmacol. 2018;175(18):3669-3684. (JCR一区,IF=6.810, 共同通讯作者)

5Simvastatin attenuated rat thoracic aorta remodeling by decreasing ROCK2‑mediated CyPA secretion and CD147‑ERK1/2‑cyclin pathway. Fu-Cai Tang#, Hong-Yan Wang#, Ming-Ming Ma #, Tian-Wang Guan#, Long Pan, Dun-Chen Yao, Ya-Lan Chen, Sheng-Jie Li, Hang Yang, Xiao-Qin Zhu, Yong-Sheng Tu*. Mol Med Rep. 2017;16(6):8123-8129. (SCI收录,IF=1.922, 共同第一作者)

6Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax translocation in rat basilar artery smooth muscle cells. Yun Liu#, Min Gao#, Ming-Ming Ma #, Yong-Bo Tang, Jia-Guo Zhou, Guan-Lei Wang, Yan-Hua Du*, Yong-Yuan Guan*. J Mol Cell Cardiol. 2016;92:122-33. (JCR一区,IF=5.680, 共同第一作者)

7 TRPC3 channel confers cerebrovascular remodelling during hypertension via transactivation of EGF receptor signalling. Mi Wang#*, Yong-Bo Tang#, Ming-Ming Ma #, Jing-Hui Chen, Chang-Ping Hu, Shui-Ping Zhao, Dao-Quan Peng, Jia-Guo Zhou, Yong-Yuan Guan, Zheng Zhang*. Cardiovasc Res. 2016;109(1):34-43. (JCR一区,IF=5.878, 共同第一作者)

8 Integrin β3 mediates cerebrovascular remodelling through Src/ClC-3 volume-regulated Cl- channel signalling pathway. Jia-Wei Zeng#, Xiao-Guang Wang#, Ming-Ming Ma #, Xiao-Fei Lv, Jie Liu, Jia-Guo Zhou, Yong-Yuan Guan*. Br J Pharmacol. 2014;171(13):3158-70. (JCR一区,IF=4.842, 共同第一作者)

9Deficiency of volume-regulated ClC-3 chloride channel attenuates cerebrovascular remodelling in DOCA-salt hypertension. Ling-Yun Zheng#, Lei Li#, Ming-Ming Ma #, Yun Liu, Guan-Lei Wang, Yong-Bo Tang, Jia-Guo Zhou, Xiao-Fei Lv, Yan-Hua Du*, Yong-Yuan Guan*. Cardiovasc Res. 2013;100(1):134-42. (JCR一区,IF=5.808, 共同第一作者)

10Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells. Xiao-Guang Wang#, Jing Tao#, Ming-Ming Ma #, Yong-Bo Tang, Jia-Guo Zhou, Yong-Yuan Guan*. Cardiovasc Res. 2013;98(3):469-78. (JCR一区,IF=5.808, 共同第一作者)

11Mitochondria dependent pathway is involved in bestrophin-3 protective effect on hydrogen peroxide-induced apoptosis in basilar artery smooth muscle cells. Lei Jiang#, Yun Liu#, Ming-Ming Ma #, Yong-Bo Tang, Jia-Guo Zhou, Yong-Yuan Guan*. Apoptosis. 2013;18(5):556-65. (SCI收录,IF=3.614, 共同第一作者)

 

学术兼职:

中国药理学会心血管药理专业委员会青年委员