医学前沿学术报告第203期—Molecular mechanism of learning and memory

题  目: Molecular mechanism of learning and memory

主讲人: Professor Yasunori Hayashi

Brain Science Institute, RIKEN, JAPAN

主持人: 蒋斌 教授

          中山大学神经科学研究中心、生理学系

时  间：2014年12月29日（星期一）下午15:00时

地  点：中山大学北校区永生楼四楼讲学厅

主讲人简介：

Professor Yasunori Hayashi obtained his Ph.D. in Molecular Physiology in Department of Pharmacology, Kyoto University in 1994 and accepted the postdoctoral trainings at University of Tokyo and at Cold Spring Harbor Laboratory (Roberto Malinow) from 1994 to 2000. He was an assistant Professor in RIKEN-MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology from 2000 to 2004. Thereafter he was a unit leader in Brain Science Institute, RIKEN since 2005. In 2013 he became a Senior Team Leader in Brain Science Institute, RIKEN, Japan.

In 1973, Bliss and Lømo made an interesting observation in rabbit hippocampus that high frequency stimulation to the synaptic input fiber, the following transmission was increased over hours. This was the first demonstration of plasticity of the synaptic transmission now called long-term potentiation---LTP. Hippocampus is responsible for memory formation as drugs or genetic manipulation that inhibits hippocampal LTP affect memory formation. Hayashi’s team currently studies the postsynaptic changes after LTP in hippocampus by combining the several technologies such GFP, dominant negative forms, viral vectors, slice culture, two-photon microscopy, and Förster energy transfer (FRET) and found that the postsynaptic structure is rapidly reorganized both structurally and chemically by LTP induction. In this talk, Dr. Hayashi will discuss the roles of quick polymerization of F-actin and translocation of cofilin in the structural modification of dendritic spine in hippocampal neurons.

欢迎各位师生踊跃参加！

中山大学中山医学院

中山大学医学科学处

2014年12月24日