免疫学前沿研究系列讲座 第1期—Tumour Necrosis Factor Signaling: Regulating host immune function ...

题 目：Tumour Necrosis Factor Signaling: Regulating host immune function against Mycobacterium tuberculosis infection 

主讲人：Prof. Muazzam Jacobs

主持人：李义平教授

时   间：2015年6月22日(星期一)下午15:00时

地   点：中山大学北校区永生楼四楼讲学厅

主讲人简介：

Prof. Muazzam Jacobs (PhD, University of Cape Town) is a joint staff member in the Division of Immunology, Department of Clinical Sciences, Health Sciences Faculty at the University of Cape Town and National Health Laboratory Service in South Africa. His main research interests include understanding host immune mechanisms during tuberculosis infection and has published particularly on the role of tumor necrosis factor in modulating host immune function.  He is a full member of the Institute of Infectious Diseases and Molecular Medicine at the University of Cape Town where he is based and leads a research group. 

Prof. Jacobs seeks to explore potential collaboration with colleagues from Sun Yat-sen University in areas of common interest that can be mutually beneficial.

SELECTED PUBLICATIONS：

1、Mycobacterium tuberculosis infection of the 'non-classical immune cell'.

Randall PJ, Hsu NJ, Quesniaux V, Ryffel B, Jacobs M.

Immunology and Cellular Biology. 2015 Apr 28. doi: 10.1038/icb.2015.43.

2、Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis.

Spanos JP, Hsu NJ, Jacobs M.

Frontiers in Cell Neuroscience. 2015 May 18;9:182. doi: 10.3389/fncel.2015.00182.

3、The C-Type Lectin Receptor CLECSF8/CLEC4D Is a Key Component of Anti-Mycobacterial Immunity

Gillian J Wilson, Mohlopheni J Marakalala, Jennifer C Hoving, Arjan van Laarhoven, Rebecca A Drummond, Bernhard Kerscher, Roanne Keeton, Esther van de Vosse, Tom HM Ottenhoff, Theo S Plantinga, Bachti Alisjahbana, Dhirendra Govender, Gurdyal S Besra, Mihai G Netea, Delyth M Reid, Janet A Willment, Muazzam Jacobs, Sho Yamasaki, Reinout van Crevel, Gordon D Brown

Cell host & microbe, 2015;17(2): 252-259

4、Neurons are host cells for Mycobacterium tuberculosis.

Philippa J Randall, Nai-Jen Hsu, Dirk Lang, Susan Cooper, Boipelo Sebesho, Nasiema Allie, Roanne Keeton, Ngiambudulu M Francisco, Sumayah Salie, Antoinette Labuschagné, Valerie Quesniaux, Bernhard Ryffel, Lauriston Kellaway, Muazzam Jacobs

Infection and Immunity, 2014, 82 (5), 1880-1890

5、Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis

Roanne Keeton, Nasiema Allie, Ivy Dambuza, Brian Abel, Nai-Jen Hsu, Boipelo Sebesho, Philippa Randall, Patricia Burger, Elizabeth Fick, Valerie FJ Quesniaux, Bernhard Ryffel, Muazzam Jacobs.

Journal of Clinical Investigation. 2014;124(4):1537–1551. doi:10.1172/JCI45005.

6、Novel non-neuroleptic phenothiazines inhibit Mycobacterium tuberculosis replication

S Salie, NJ Hsu, D Semenya, A Jardine, M Jacobs

Journal of Antimicrobial Chemotherapy 2014, 69 (6), 1551-1558

7、Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection.

Allie, N., Grivennikov, S.I., Keeton, R., Hsu, N.-J., Bourigault, M.-L., Court, N., Fremond, C., Yeremeev, V., Shebzukhov, Y., Ryffel, B., Nedospasov, S.A., Quesniaux, V.F.J., Jacobs, M.

Scientific Reports (2013) 3:1809

                                         中山医学院免疫学教研室