导师资格：博士生导师

所在教研室/单位： 微生物学教研室

E-mail：liangjk5@mail.sysu.edu.cn

通信地址： 广州市越秀区中山二路74号大院科技综合楼

办公电话：020-87333258

研究方向：为溶瘤病毒，专注溶瘤病毒的肿瘤靶向性分子机制、免疫学特性和新毒种研究。

个人简历

    中山大学，中山医学院，副教授。研究方向为溶瘤病毒抗肿瘤疗法。在溶瘤病毒靶向肿瘤的分子机制、免疫杀伤机制和新毒种研究方面取得系列成果，以第一作者或通讯作者在Nature Communications、Advanced Science、Cell Reports Medicine等国际期刊发表十余项研究论文。主持国家、省、市及校级科研项目9项，包括国家自然科学基金4项、广东省自然科学基金杰出青年项目和广州市民生科技攻关项目等。

 

学术成果

学术论著

  1. Fan Z, Liu Y, Lin X, Zhang J, Chen J, Yi S, Hu C, Liu X, Guo C, Xu C, Chen X, Tian X, Liang X, Liu Y, Hu L, Huang S, Guo L, Zhu W, Hu J, Yan G, Lin Y, Cai J, Liang J (co-corresponding author) (2025) Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction. Nat Commun 16(1):6136
  2. Hu L, Zhang G, Lin Y, Yi S, Yang J, Lin X, Song D, Liu Z, Zhang J, Zeng Y, Huang S, Fan Z, Zhang J, Liu Y, Hu C, Zhu W, Yin W, Hu J, Yan G, Cai J, Liang J (co-corresponding author) (2025) Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1. Adv Sci (Weinh) 12(48):e10597
  3. Dan J, Cai J, Zhong Y, Wang C, Huang S, Zeng Y, Fan Z, Xu C, Hu L, Zhang J, Hu J, Liu Y, Su X, Zhu W, Yan G, Liang J (co-corresponding author), Lin Y (2023) Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine. Cell Rep Med 4(10):101229
  4. Guo L, Hu C, Liu Y, Chen X, Song D, Shen R, Liu Z, Jia X, Zhang Q, Gao Y, Deng Z, Zuo T, Hu J, Zhu W, Cai J, Yan G, Liang J (co-corresponding author), Lin Y (2023) Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile. Nat Commun 14(1):3410
  5. Bai W, Tang X, Xiao T, Qiao Y, Tian X, Zhu B, Chen J, Chen C, Li Y, Lin X, Cai J, Lin Y, Zhu W, Yan G, Liang J(co-corresponding author), Hu J (2024) Enhancing antitumor efficacy of oncolytic virus M1 via albendazole-sustained CD8(+) T cell activation. Mol Ther Oncol 32(2):200813
  6. Dan J, Nie L, Jia X, Xu C, Cai J, Lin Y, Hu J, Zhu W, Li Y, Chen D, Liu Y, Hu C, Yan G, Liang J(co-corresponding author), Zhang Q (2021) Visualization of the Oncolytic Alphavirus M1 Life Cycle in Cancer Cells. Virologica Sinica 
  7. Liu Y, Li K, Zhu WB, Zhang H, Huang WT, Liu XC, Lin Y, Cai J, Yan GM, Qiu JG, Peng L, Liang JK(co-corresponding author), Hu C (2021) Suppression of CCDC6 sensitizes tumor to oncolytic virus M1. Neoplasia 23(1):158-168