导师资格：硕士生导师

所在教研室/单位： 中山医学院

E-mail：zhangyw57@mail.sysu.edu.cn

研究方向：免疫应答调控

个人简介

张译文博士，中山大学中山医学院副教授、广东省杰出青年基金获得者、中山大学 “逸仙新锐学者”。 2011年本科毕业于中南大学湘雅医学院，2016年博士毕业于中山大学中山医学院。作为第一作者及通讯作者在Immunity，Nat Immunol，PNAS，Signal Transduct and Tar，Cell Mol Immunol，J Immunother Cancer，Cancer Res，Cell Rep，Adv Sci，J Nanobiotechnol等发表论文十余篇。主持国家自然科学基金重大研发计划（培育项目）、面上项目及青年项目。

 

研究方向

实验室目前的研究主要围绕方向：

  1. 抗病毒感染及疫苗的粘膜免疫应答机制

    研究呼吸道粘膜组织在抗病毒免疫中的作用，解析病毒感染和疫苗诱导的粘膜免疫应答规律。

  2. 慢性感染与持续抗原刺激下的免疫应答机制

    探索长期抗原刺激对免疫细胞功能的影响，包括T细胞耗竭、组织驻留型免疫细胞记忆形成及免疫调控机制。

 

学术成果

第一作者及通讯作者代表性学术论著（按时间排序）：

  1. Liang C#, Li R#, Pu Z#, Chen R#, Li Y#, Chen S#,… Zhang Y*, Targeting Heptad Repeats and Fusion Peptide: Nanoparticle Vaccine Elicits Mucosal Immune Response Against SARS-CoV-2 Variants, Journal of Nanobitechnology, (2025)23:483.(中科院一区TOP，IF：12.3)
  2. Hao W…… Zhang Y*, Li W*, Liu H*. IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis. Advanced Science, 2025, 12(18):2500952 (中科院一区TOP，IF：14.1)
  3.  He X#, Zhang X#, Wu B#, Deng J#, Zhang Y#… …Zhao J*, Wei J*, Chen R*, Zhang Y*, Zhang H*; The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis, Nature Immunology, 2024, 25(4) (中科院一区TOP，IF：27.7)
  4. Feng J#, Pu Z#..., Zhang H*, Zhang Y*; Correlation between Circulating T Follicular Helper Cell Levels after Infection and a Decreased Risk of COVID-19 Re-infection. Virologica Sinica (2024): S1995-820X. (中科院二区)
  5. Chen Y#, Yan S#, ... Huang F*, Zhang H*, Zhang Y*. Dopamine/DRD5 Signaling Axis Modulates CD8+ T cells into the CD103+ Tissue-resident Memory Fate and Their Antitumor Immunity. Cancer Research. 2022, 82(17): 3130-3142. (中科院一区TOP，IF：13.4)
  6. Zhang Y#, Li R#, Li Y#, ... Zhang H*, He Y*. Antibody Response and Cross-Neutralization After Omicron BA.2 Infection. Signal Transduction and Targeted Therapy. 2023, 8(1). (中科院一区TOP，IF：52.2)
  7. Zhang Y , ... Zhang J*, Zhang H*. The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Downregulating MHC-Ι. Proceedings of the National Academy of Sciences, 2021, 118(23) . (中科院一区TOP，IF：10.6)(ESI高引论文)
  8. Zhang Y , ... Li B*, Zhang H*. Amino Acids and RagD Potentiate mTORC1 Activation in CD8+ T Cells to Confer Antitumor Immunity. Journal for ImmunoTherapy of Cancer, 2021, 9(4). (中科院一区，IF：11.5)
  9. Yuan Y#, Zhang X#, Chen R#, ..., Zhang Y*, and Zhang H*. A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2. Cell Reports. 2021: 110256. (中科院一区，IF：7.5)
  10. Ma X#, Zou F#, Yu F#, Li R#, Yuan Y#, Zhang Y#, ... Zhang H. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Immunity. 2020, 53(6): 1315-1330. e9. (中科院一区TOP，IF：33.2)
  11. Pan T#, Hu Z#, Hu F#, Zhang Y#, ... Tang X*, Zhang H*. Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains. Cellular & Molecular Immunology. 2021: 1-3. (中科院一区TOP，IF：22.6)
  12. Zhang Y #, Chen Y#, ... Wei L*, Zhang H*. UHRF1 Controls Thymocyte Fate Decisions Through the Epigenetic Regulation of EGR1 Expression. Journal of Immunology. 2020, 204(12): 3248-3261.
  13. Luo B#, Zhan Y#, ..., Zhang Y*, Zhang H*. Engineered Production of Anti-PD1 Antibody-Expressing Long-lived Plasma Cells by CRISPR/CAS9-Mediated Targeted Gene Integration.Cell Death and Diseases.2020 Nov 12;11(11):973.
  14. Zhang Y，..., Liu B*, and Zhang H*. A cellular microRNA facilitates regulatory T lymphocyte development by targeting the FOXP3 promoter TATA-box motif. Journal of Immunology. 2018. 200(3):1053-1063.
  15. Pan T, ..., Zhang Y*, and Zhang H*. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Potently Inhibit the Replication of Zika Viruses by Inducing the Degradation of Axl. Journal of Virology. 2018, 92(20): e01018-18.
  16. Chen Y#, Yu F #, ..., Li L*, and Zhang Y*. Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth. Journal of Immunotherapy. 2018, 41(6): 274. (IF:4.5).