个人简介

中山大学副教授；2015年毕业于中山医学院，获临床医学学士学位；2020年毕业于中山大学附属第一医院，获外科学博士学位；后在中山医学院开展博士后及特聘副研究员工作，2024年转聘副教授。

围绕“睾丸间质细胞与男性生殖健康”进行研究，以通讯或第一作者（含共同）发表论文多篇；参与制定临床诊疗专家共识2项；申请中国发明专利7项，已授权2项，申请国际PCT专利1项；主持国家自然科学基金、中国博士后基金、广东省自然基金等项目。

学术成果

（# co-first author; *co-corresponding author）

  1. Xia K#, Zhang S#, Peng H#, Chen H#, Yang C, Yu J, Luo P, Lu Q, Chen H, Huang L, Xiong Y, Zhao L, Jia L, Li L, Qiu Y, Guo Y, Liu C, Fan H, Dai Z, Liu G, Ke Q, Wang T, Li W, Chen L*, Deng C*, Xiao H*, Xiang AP*. An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis. Nat Cell Biol. 2026
  2. Liu C#, Peng H#, Yu J#, Luo P#, Xiong C, Chen H, Fan H, Ma Y, Ou W, Zhang S, Yang C, Zhao L, Zhang Y, Guo X, Ke Q, Wang T, Deng C, Li W, Xiang AP*, Xia K*. Impaired ketogenesis in Leydig Cells drives testicular aging. Nat Commun. 2025
  3. Xia K#, Wang F#, Lai X#, Dong L#, Luo P, Zhang S, Yang C, Chen H, Ma Y, Huang W, Ou W, Li Y, Feng X, Yang B, Liu C, Lei Z, Tu X, Ke Q, Mao FF, Deng C*, Xiang AP*. AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure. Cell Rep Med. 2022
  4. Yu J#, Yang C#, Guo Y#, Dai Z#, Luo P, Zhang Y, Peng H, Zhang S, Liu C, Zhao L, Fan H, Xiong Y, Xie Q, Jia L, Yu X, Wang T, Li W, Ke Q, Zheng F, Deng C*, Xiang AP*, Chen H*, Xia K*. Tracing the origin of testosterone-producing Leydig cells during postnatal development and regeneration. Cell Rep. 2025
  5. Xia K#, Wang F#, Tan Z#, Zhang S#, Lai X, Ou W, Yang C, Chen H, Peng H, Luo P, Hu A, Tu X, Wang T, Ke Q, Deng C*, Xiang AP*. Precise correction of Lhcgr mutation in stem Leydig cells by prime editing rescues hereditary primary hypogonadism in mice. Adv Sci. 2023
  6. Zhang S#, Yang B#, Shen X#, Chen H#, Wang F, Tan Z, Ou W, Yang C, Liu C, Peng H, Luo P, Lei Z, Yan S, Wang T, Ke Q, Deng C, Xiang AP*, Xia K*. AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure. Cell Prolif. 2024
  7. Xia K#, Chen H#, Wang J#, Feng X#, Gao Y, Wang Y, Deng R, Wu C, Luo P, Zhang M, Wang C, Zhang Y, Zhang Y, Liu G, Tu X, Sun X, Li W, Ke Q*, Deng C*, Xiang AP*.Restorative functions of autologous stem Leydig cell transplantation in a testosterone-deficient non-human primate model. Theranostics. 2020
  8. Xia K#, Luo P#, Yu J#, He S#, Dong L, Gao F, Chen X, Ye Y, Gao Y, Ma Y, Yang C, Zhang Y, Yang Q, Han D, Feng X, Wan Z, Cai H, Ke Q, Wang T, Li W, Tu X, Sun X, Deng C*, Xiang AP*. Single-cell RNA Sequencing Reveals Transcriptomic Landscape and Potential Targets for Human Testicular Ageing. Hum Reprod. 2024
  9. Xia K, Ma Y, Feng X, Deng R, Ke Q, Xiang AP*, Deng C*. Endosialin defines human stem Leydig cells with regenerative potential. Hum Reprod. 2020