中山大学教授和华南颅颌干细胞中心主任，宾夕法尼亚大学客座教授。任美国NIDCR/NIH Equipment Survey 委员， NIH评审专家，美国国家标准技术研究院评审专家，肯塔基科学工程基金评审专家；J Endodontics 杂志顾问委员，AAE顾问委员，Stem Cell Research & Therapy、Oral Diseases 等多个国际口腔主要杂志编委。

       作为通讯作者在Nat Medicine, Cell Stem Cell, Cell Metabolism, Immunity, Lancet, J Clin Invest, Nat Biotechnol, Nature Communication, Science Translational Medicine, Journal of Experimental Medicine, Proc Natl Acad Sci U S A, Cell Research, Blood, EMBO Mol Med, Cell Death Differ等杂志发表论文200多篇，引用次数超过 58,000 余次, H-index：102。 (http://scholar.google.com/citations?user=q1HfzhoAAAAJ&hl=en)。获得国际专利20余项，为国家杰出青年基金和创新千人获得者。2013年获IADR 牙髓生物学优秀科学家奖, 2020年获口腔生物医学杰出贡献奖 (中华口腔医学会)

       施松涛教授拥有美国牙医执照并曾在美国国立卫生院附属医院从事临床工作，同时长期从事口腔再生医学及其临床转化方面的研究工作。首次从人体组织中分离鉴定牙髓干细胞、脱落乳牙干细胞、牙周膜干细胞、根尖牙乳头干细胞、肌腱干细胞, 牙龈间充质干细胞等，研究成果被维基百科列为 2003 年度干细胞研究领域的里程碑。

 

已发表SCI论文（*通讯作者）

  1. Ma, L., C. Chen, D. Liu, Z. Huang, J. Li, H. Liu, R. T. Kin Kwok, B. Tang, B. Sui, X. Zhang, J. Tang, X. Mao, W. Huang, S. Shi* and X. Kou*. Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair. Bioact Mater. 2023. 19: 626-641.[IF:14.59]
  2. Qianmin Ou,Lingping Tan,Yiting Shao,Fangcao Lei,Weiying Huang,Ning Yang,Yan Qu,Zeyuan Cao,Luhan Niu,Yao Liu,Xiaoxing Kou*,Songtao Shi*., Electrostatic Charge-Mediated Apoptotic Vesicle Biodistribution Attenuates Sepsis by Switching Neutrophil NETosis to Apoptosis. Small 2022, doi.org/10.1002/smll.202200306. [IF:13.28]
  3. He, Y., Y. Qu, B. Meng, W. Huang, J. Tang, R. Wang, Z. Chen, X. Kou* and S. Shi*. "Mesenchymal stem cells empower T cells in the lymph nodes via MCP-1/PD-L1 axis." Cell Death Dis 2022, 13(4): 365.[IF:5.96]
  4. Zheng, C.; Sui, B.; Zhang, X.; Hu, J.; Chen, J.; Liu, J.; Wu, D.; Ye, Q.; Xiang, L.; Qiu, X.; Liu, S.; Deng, Z.; Zhou, J.; Liu, S. *; Shi, S. *; Jin, Y. *, Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes. J Extracell Vesicles 2021, 10 (7), e12109.[IF:25.84]
  5. Yu, W.; Chen, C.; Kou, X.; Sui, B.; Yu, T.; Liu, D.; Wang, R.; Wang, J.; Shi, S., Mechanical force-driven TNFalpha endocytosis governs stem cell homeostasis. Bone Res 2021, 8 (1), 44. [IF:12.5]
  6. Ma, L.; Huang, Z.; Wu, D.; Kou, X.; Mao, X.; Shi, S., CD146 controls the quality of clinical grade mesenchymal stem cells from human dental pulp. Stem cell research & therapy 2021, 12 (1), 488. [IF:5.5]
  7. Li, W.; Jiao, X.; Song, J.; Sui, B.; Guo, Z.; Zhao, Y.; Li, J.; Shi, S. *; Huang, Q. *, Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function. Stem Cells Transl Med 2021. [IF:6.4]
  8. Fu, Y.; Sui, B.; Xiang, L.; Yan, X.; Wu, D.; Shi, S. *; Hu, X. *, Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy. Cell Death Dis 2021, 12 (6), 596. [IF:6.9]
  9. Tian, J.; Kou, X.; Wang, R.; Jing, H.; Chen, C.; Tang, J.; Mao, X.; Zhao, B.; Wei, X.; Shi, S., Autophagy controls mesenchymal stem cell therapy in psychological stress colitis mice. Autophagy 2020, 1-18. [IF:12.3]
  10. Sui, B.; Wu, D.; Xiang, L.; Fu, Y.; Kou, X.; Shi, S., Dental Pulp Stem Cells: From Discovery to Clinical Application. Journal of endodontics 2020, 46 (9S), S46-S55. [IF:3.4]
  11. Li, B.; He, X.; Dong, Z.; Xuan, K.; Sun, W.; Gao, L.; Liu, S.; Liu, W.; Hu, C.; Zhao, Y.; Shi, S. *; Jin, Y.*, Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca(2+) channel internalization in mesenchymal stem cells. Bone Res 2020, 8, 19. [IF:12.5]
  12. Sui, B.; Chen, C.; Kou, X.; Li, B.; Xuan, K.; Shi, S. *; Jin, Y.*, Pulp Stem Cell-Mediated Functional Pulp Regeneration. J Dent Res 2019, 98 (1), 27-35. [IF:6.1]
  13. Tingting Yu, Dawei Liu, Ting Zhang, Yanheng Zhou, Songtao Shi* & Ruili Yang* Inhibition of Tet1- and Tet2-mediated DNA demethylation promotes immunomodulation of periodontal ligament stem cells, Cell Death & Disease 2019,10: 780. [IF:6.9]
  14. Kou X, Xu X, Chen C, Sanmillan ML, Cai T, Zhou Y, Giraudo C, Le A, Shi S*.,The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing, Sci Transl Med.2018;10(432). DOI: 10.1126/scitranslmed.aai8524[IF:16.79]
  15. Chen C, Wang D, Moshaverinia A, Liu D, Kou X, Yu W, Yang R, Sun L*, Shi S*, Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis Cell Res2017, 27(4): 559-577[IF:15.60]
  16. Liu S, Liu D, Chen C, Hamamura K, Moshaverinia A, Yang R, Liu Y, Jin Y*, Shi S* MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus, Cell Metab2015, 22(4):606-618[IF:18.16]
  17. Yang R, Qu C, Zhou Y, Konkel J, Shi S, Liu Y, Chen C, Liu S, Liu D, Chen Y, Zandi E, Chen W, Zhou Y*, Shi S* Hydrogen Sulfide Promotes Tet1- and Tet2-mediated Foxp3 Demethylation to Regulate Regulatory T Cell Differentiation and Function，Immunity 2015,3(2):251-63[F:22.845]
  18. Moshaverinia A, Chen C, Xu X, Ansari S, Paine ML, Moradian-Oldak J, Zadeh HH, Schricker SR, Khademhosseini A, Snead ML*,  Shi S* Regulation of the stem cell-host immune system interplay using hydrogel co-encapsulation system with an anti-inflammatory drug, Advanced Functional Materials2015, 25(15):2296-2307[IF:12.12]
  19. Chen C, Akiyama K, Wang D, Xu X, Li B, Moshaverinia A, Brombacher F, Sun L*, Shi S* mTOR Inhibition Rescue Osteopenia in Mice with Systemic Sclerosis J Exp Med 2015, 212(1):73-91[IF:11.99]
  20. Liu Y*, Yang R, Liu X, Zhou Y, Qu C, Kikuiri T, Wang S, Zandi E, Du J, Ambudkar JS, Shi S* Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca2+ Channel Sulfhydration Cell Stem Cell 2014, 5(1):66-78[IF:23.39]
  21. Zhang Q#, Atsuta I#, Liu S, Chen C, Shi S, Shi S*, Le A* IL-17-mediated M1/M2 Macrophage Alteration Contributes to Pathogenesis of Bisphosphonate-related Osteonecrosis of the Jaws Clin Cancer Res.2013, 9(12): 3176-3188[IF:9.62]
  22. Yang R#, Li Y#, Kelk P, Qu C, Akiyama K, Chen C, Atsuta I, Chen W-J, Zhou Y*, Shi S* A subset of IL-17+ Mesenchymal Stem Cells Possesses Anti-Candida Albicans Effect Cell Research 2013. 23(1):107-121[IF:15.61]
  23. Akiyama K#, Chen C#, Wang D#, Xu X, Qu C, Yamaza T, Cai T, Chen WJ, Sun L*, Shi S*. Mesenchymal Stem Cell-Induced Immunoregulation Involves Fas Ligand/Fas-Mediated T Cell Apoptosis Cell Stem Cell.2012, 10(5): 544-555[IF:23.39]
  24. Liu Y, Wang L, Kikuiri T, Akiyama K, Chen C, Xu X, Yang R, Chen W-J, Wang S, Shi S*. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-αa Nat Med2011. 17:1594-1602[IF:29.89]

 

获得科研基金项目

  1. “珠江人才计划”引进创新创业团队项目（2020.8-2025.8），2000万元 项目负责人

题目：颅颌干细胞免疫调节及组织再生在牙周病治疗中的新策

  1. 国家科技重大专项（2018.1-2020.12），500万元 子项目负责人

题目：乙肝相关肝病的干细胞治疗及新型免疫治疗技术研发

  1. 国家重点研发计划（2021.12-2026.6）2600万元 项目负责人

题目：牙颌组织发育与再生中颅颌干细胞谱系分化及其微环境调控

  1. GINGIVA DERIVED MSCS: ROLE IN IMMUNOMODULATION AND TISSUE REGENERATION（2009-2014）200万美元 项目负责人
  2. Oral and Craniofacial Reconstruction Using MSCs（2008-2013）200万美元 项目负责人
  3. Stem Cell Based Therapy for Regenerative Endodontics（2008-2013）32万美元 项目负责人
  4. Osteogenic Mechanisms of SHED（2007-2012）87万美元 项目负责人
  5. INTERPLAYS BETWEEN THE JAW MESENCHYMAL STEM CELLS AND T LYMPHOCYTES（2009-2011）50万美元 项目负责人

 

获得授权专利

1. Adult Human Dental Pulp Stem Cells in vitro and in vivo，US 7,052,907，Shi S., Gronthos S., Robey P.G. 2006.5.30

2. Multipotent Postnatal Stem Cells from Human Periodontal Ligament，US20070009492A1，Muira M., Shi S., Seo B. M.，2007.1.11

3. Postnatal Stem Cells and Uses Thereof, US20070274958A1, Shi S., Robey P.G., Muira M, Gronthos S , 2007.11.29

4. The Use of Mesenchymal Stem Cells and The Separating and Preserving Method of Stem Cells from Human Tissues, WO/2008/071074, Wang S., Shi S., Xu Y, 2008.6.19

5. Skeletal Site-Specific Characterization of Orofacial and Iliac Crest Human Bone Marrow Stromal Cells in Same Individuals, US2009/0148418A1, Akintoye S., Shi S.,  Robey P, 2009.6.11

6. Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration, US2010/0196854, Shi S., Sonoyama W., Yamaza T., Wang S,2010.4.21

7. Perivascular Mesenchymal Precursor Cells, US 7,947,266, Gronthos S., Zannettino A., Shi S,2011.4.24

8. Stem Cell Modified Animal Model for Aging-Related Degenerations, Stem Cell Based Methods and Compositions for Extending Lifespan and Treating SLE-Like Autoimmune Diseases, US2011/0283371A1, Shi S., Yamaza T., Kentaro A, 2011.11.17

9. Perivascular Mesenchymal Precursor Cells, Australian Patent Application No: AU2011253969A, Gronthos S., Shi S., Zannettino A., 2011.12.12

10. Gingiva Derived Stem Cell and Its Application in Immunomodulation and Reconstruction, US2012/0128636A1, Le A. D., Zhang Q, Shi S,2012.5.24

11. 一种干细胞冻存液，202010797418.5，寇晓星、施松涛

12. 一种牙髓干细胞冻存液及其冻存方法，202010796891.1，寇晓星、施松涛

 

获得科研奖励

  1. 口腔生物医学杰出贡献奖 (中华口腔医学会)，2020年
  2. Distinguished Scientist Award for Pulp Biology & Regeneration， 国际牙科研究学会（美国），IADR杰出科学家奖，2013年
  3. Oral and Craniofacial Reconstruction Using Mesenchymal Stem Cells，南加州大学再生医学研究所（美国），New Faculty Award，2008.2