博士,中山大学教授,博士生导师,国家高层次引进人才青年项目入选者,中山大学“百人计划”引进人才。2007年毕业于山东大学,获得理学学士学位,2013年毕业于中国科学院上海生命科学研究院,获得理学博士学位,2013年至2014年在哥伦比亚大学从事免疫学相关研究,2014-2021年在美国爱因斯坦医学院Paul Frenette教授指导下从事的造血干细胞、神经免疫和肠道菌群的相关研究。2021年-2022年于香港中文大学担任助理教授。2022年1月起在中山大学中山医学院开始工作。

   致力于干细胞和免疫微环境的研究,主要学术贡献如下:1) 精神压力通过肠道菌群促进血管炎症和疾病的发生 (Immunity, 2020); 2) 疼痛神经通过 CGRP 抑制炎症反应 (JEM, 2021); 3) 环境因素促进血管炎症和疾病的发生 (Nature Medicine, 2018); 4) 骨髓动脉血管通过分泌干细胞因子调控造血干细胞的维持和再生 (Nature Communications, 2018)。近年来在包括Nature、Nature Medicine 、Immunity 、Cell Stem Cell, Nature Communications 、Journal of Experimental Medicine 和Blood 等国际学术期刊累计发表论文30余篇,被引用3700余次。

 

代表性论文:

  1. Xu C, Lee SK, Zhang D, Frenette PS. The gut microbiome regulates psychological stress-induced inflammation. Immunity, 2020 Aug 18;53(2):417-428.e4. (Highlighted by NatureGut microbes and stress team up to make a painful disease worse.) (Preview in Immunity: Gut Feelings Block the Flow: Microbiota Links Stress to Vascular Disease)
  2. Xu C, Frenette PS. Seasonal manifestations of sickle cell disease. Nature Medicine. 2019 Apr;25(4):536-537.
  3. Xu C, Gao X, Wei Q, Nakahara F, Zimmerman SE, Mar J, Frenette PS. Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow. Nature Communications. 2018 Jun;9(1):2449.
  4. Xu C, Gulinello M, Frenette PS. Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage. Journal of Experimental Medicine, 2021. 218 (1): e20200065. (Highlighted by Science Translational MedicineA spicy solution for sickle cell disease.)
  5. Zhang D*, Xu C*, Manwani D*, Frenette PS. Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology. Blood. 2016 Feb;127(7):801-9. (* equal contribution).  
  6. Gao X, Zhang D*, Xu C*, Li H, Caron KM, Frenette PS. Nociceptive nerves regulate haematopoietic stem cell mobilization. Nature. 2021 Jan;589(7843):591-596. (*Equal contribution).
  7. Xu C, Lin L, Cao G, Chen Q, Shou P, Huang Y, Han Y, Wang Y, Shi Y. IFNα-secreting MSCs exerts potent anti-tumor effect in vivo. Oncogene. 2014 Oct;33(42):5047-52.
  8. Xu C, Yu P, Han X, Du L, Gan J, Wang Y, Shi Y. Transforming growth factor β promotes immune responses in the presence of mesenchymal stem cells. The Journal of Immunology. 2014 Jan;192(1):103-9. (Highlighted in the “In This Issue” section).
  9. Xu C, Ren G, Cao G, Chen Q and Shou P, Zheng C, Du L, Han X, Jiang M, Yang Q, Lin L, Wang G, Yu P, Zhang X, Cao W, Brewer G, Wang Y, Shi Y. miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. The Journal of Biological Chemistry. 2013 Apr;288(16):11074-9.