导师资格：硕士生导师

所在教研室/单位： 组织胚胎学教研室

E-mail：zhangbao5@mail.sysu.edu.cn

研究方向：人胚胎肢体发育与再生

个人简介：

张宝博士，中山大学中山医学院副教授，硕士生导师。2022年博士毕业于中山大学中山医学院；2022-2025年在中山大学中山医学开展博士后研究工作。主要从事人胚胎肢体发育与再生及母婴健康研究工作，取得了多项研究成果，近五年共发表高水平SCI论文10篇，累计影响因子142.2（篇均 15.8），并获软件著作权1 项，发明专利1 项。重点聚焦于利用单细胞多组学技术研究肢体发育与再生，研究工作首次构建了人胚胎发育的单细胞时空图谱，相关成果发表于Nature、Science Bulletin、Cell Proliferation、Bioactive Meterials及Chemical Engineering Journal等。获得国家自然科学青年基金项目资助。

代表性学术成果：

（* co-first author，# co-corresponding author）

  1. Zhang Bao*, He Peng*, Lawrence John E G *, Wang Shuaiyu*, TuckElizabeth , Williams Brian A, Roberts Kenny, Kleshchevnikov Vitalii, Mamanova Lira, Bolt Liam, Polanski Krzysztof, Li Tong, Elmentaite Rasa,Fasouli Eirini S, Prete Martin, He Xiaoling, Yayon Nadav, Fu Yixi, Yang Hao, Liang Chen, Zhang Hui, Blain Raphael, Chedotal Alain, FitzPatrick David R, Firth Helen, Dean Andrew, Bayraktar Omer Ali, Marioni John C, Barker Roger A, Storer Mekayla A, Wold Barbara J, Zhang Hongbo#, Teichmann Sarah A#. A human embryonic limb cell atlas resolved in space and time. Nature, 2024 Nov;635(8039):668-678. doi: 10.1038/s41586-023-06806-x. (48.5/Q1).

  2. Zhang Bao*, Zhang Hongbo#. The human limb cell atlas: Charting uncharted territories and setting sail on the new voyage of limb development research. Science Bulletin, 2025 Jan 15;70(1):10-13. doi: 10.1016/j.scib.2024.07.031. (21.1/Q1).

  3. Ge Li*, Li-Jun Huang*, Bao Zhang*, Shu Liu, Jing-Hua Liang, Ying Ding, Xiang Zeng, Bi-Qin Lai, Yuan-Huan Ma, Ya-Qiong Wang, Rui Wang, Hong-Bo Zhang, Yuan-Shan Zeng#.The LINGO-1-deficient neural stem cell-derived neural tissueoid showed enhanced retention and neuronal relay in the transected spinal cord. Chemical Engineering Journal, Volume 497, 2024, 155032. (13.2/Q1)

  4. Chen Yihan*, Zhang Bao*, Liu Tianliang, Chen Xiaoping, Wang Yaning, Zhang Hongbo#. T Cells with Activated STAT4 Drive the High-Risk Rejection State to Renal Allograft Failure After Kidney Transplantation. Frontiers in Immunology. 2022 Jul 1:13:895762. doi: 10.3389/fimmu.2022.895762. (5.9/Q1).

  5. Guo Fang*,Zhang Bao*, Yang Hao*, Fu Yixi, Wang Yaning, Huang Jianming, Cheng Mi, Li Xiaobo, Shen Zhuojian, Li Li, He Ping, Xiang Andy Peng, Wang Shuaiyu, Zhang Hongbo#. Systemic transcriptome comparison between early- and late- onset pre-eclampsia shows distinct pathology and novel biomarkers. Cell Proliferation. 2021 Feb;54(2):e12968. doi: 10.1111/cpr.12968. (5.6/Q2).

  6. Li Ge*, Zhang Bao, Sun Jiahui, Shi, Liyang, Huang Mengyao, Huang Lijun, Lin Zijing, Li Qiongyu, Lai Biqin, Ma Yuanhuan, Jiang Bin, Ding Ying, Zhang Hongbo, Li Miaoxin, Zhu Ping, Wang Yaqiong, Zeng Xiang, Zeng Yuanshan#. An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury. Bioactive materials. 2021 (IF: 16.874).

  7. Lai, Biqin*, Bai Yurong*, Han Weitao, Zhang Bao, Liu Shu, Sun Jiahui, Liu Jialin, Li Ge, Zeng Xiang, Ding Ying, Ma Yuanhuan; Zhang Ling, Chen Zhenghong, Wang Jun, Xiong Yuan, Wu Jinhua, Quan Qi, Xing Lingyan; Zhang Hongbo; Zen Yuanshan#. Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair. Bioactivematerials. 2022 (IF:16.874).

科研项目:

  1. 国家自然科学基金青年科学基金项目, 2025-01-01至2027-12-31, 主持