徐春亮，中山大学中山医学院教授，博士生导师，中组部“海外高层次人才”青年项目获得者，中山大学“百人计划”引进人才，逸仙学者。

教育经历

2003-2007    山东大学，生物技术基地班，理学学士；

2007-2013    中科院上海生命科学研究院/上海交通大学医学院健康科学研究所，细胞生物学博士学位，导师：时玉舫教授

工作经历

2013-2014    哥伦比亚大学，博士后，合作导师： Remi Creusot

2014-2018    爱因斯坦医学院, 博士后，合作导师：Paul Frenette

2018-2021    爱因斯坦医学院, 副研究员（Associate），合作导师：Paul Frenette

2021-2022    香港中文大学, 博士生导师、独立PI

2022- 至今     中山大学中山医学院，教授

研究方向

      本实验室致力于研究体液免疫记忆和疫苗免疫，致力于解析长寿浆细胞介导的免疫记忆维持机制，并基于此开发颠覆性技术以期实现所有疫苗的高效和长效。实验室之前工作发表在Nature、Nature Medicine 、Immunity 、Cell Stem Cell, Nature Cell Biology 、Journal of Experimental Medicine和Blood等国际学术期刊，累计发表论文30余篇，被引用6500余次。本实验室长期招收具有生物学, 基础医学和临床医学等相关专业背景的硕士生、博士生和博士后，欢迎有志于免疫学研究的同学邮件联系！

体液免疫是适应性免疫的重要组成部分，通过记忆B细胞和长寿命浆细胞维持长期的免疫保护。其中，长寿命浆细胞（Long-lived plasma cells，LLPCs）能够在骨髓中长期存活，并持续分泌中和抗体，为机体提供持久保护。近年来，关于LLPCs存活机制的研究逐渐揭示这一过程的复杂性——骨髓微环境、免疫信号通路以及代谢状态等因素，都对其存活与功能具有重要影响。禁食作为一种流行的营养干预手段，近年来备受关注。许多研究表明，禁食通过影响代谢途径和调节免疫反应，能够对健康产生积极影响：促进脂肪燃烧、延缓衰老、促进长寿、增强自噬、降低炎症反应、改善胰岛素敏感性等。然而，尽管禁食在健康方面显示出潜在的益处，禁食对体液免疫系统的影响仍然是一个备受关注和争议的话题，尤其是禁食对体液免疫记忆的作用，是否能够带来同样的益处？

我们团队近日在Immunity杂志在线发表题为Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells的研究论文，首次系统揭示间歇性禁食通过酮体代谢产物β-羟基丁酸（BHB）介导骨髓中长寿浆细胞耗竭，进而损害体液免疫记忆、削弱疫苗保护效果。这一发现警示我们：禁食并非"百利而无一害"，其代谢途径可能对免疫系统造成意想不到的负面影响。

发表论文

  1. Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells. Immunity. 2026 Feb 23:S1074-7613(26)00003-8.Zhu Y, Ding B, Lv H, Xu H, Chen J, Xu J, Wu Q, Hao X, Hu Y, Guo J, Chen J, Liang C, Li Y, We J, Cao N, Zhao J, Ren G, Jin H, Zhang Y, Li Y, Zhang H, Xu C. (唯一通许作者)

    Highlighted by Nat Rev Immunol: Intermittent fasting evicts long-lived plasma cells from survival niche.

  2. The gut microbiome regulates psychological stress-induced inflammation. Immunity, 2020 Aug 18;53(2):417-428.e4. Xu C, Lee SK, Zhang D, Frenette PS. 

    Highlighted by Nature:Gut microbes and stress team up to make a painful disease worse.

    Preview in Immunity: Gut Feelings Block the Flow: Microbiota Links Stress to Vascular Disease.

    Highlighted by Science Translational Medicine:A gut feeling to stress enhances neutrophil-mediated vascular occlusion.

  3. Seasonal manifestations of sickle cell disease. Nature Medicine. 2019 Apr;25(4):536-537. Xu C, Frenette PS. 

  4. Nociceptive nerves regulate haematopoietic stem cell mobilization. Nature. 2021 Jan;589(7843):591-596. Gao X, Zhang D*, Xu C*, Li H, Caron KM, Frenette PS. (*Equal contribution). 

  5. Brain motor and fear circuits regulate leukocytes during acute stress. Nature. 2022 May. Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C, Kahles F, He S, Janssen H, Mindur JE, Singh S, Kiss MG, Alonso-Herranz L, Iwamoto Y, Kohler RH, Wong LP, Chetal K, Russo SJ, Sadreyev RI, Weissleder R, Nahrendorf M, Frenette PS, Divangahi M, Swirski FK. 
  6. Neutrophil ageing is regulated by the microbiome. Nature. 2015 Sep;525(7570):528-32. Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith J, Burk R, Kunisaki Y, Jang J, Scheiermann C, Merad M, Frenette PS. 
  7. Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology. Blood. 2016 Feb;127(7):801-9. Zhang D*, Xu C*, Manwani D*, Frenette PS. (* equal contribution).
  8. The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.Cell Stem Cell. 2022 Feb 3;29(2):232-247. Zhang D, Gao X, Li H, Borger DK, Wei Q, Yang E, Xu C, Pinho S, Frenette PS.
  9. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell. 2012 Dec;11(6):812-24. Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan ZR, Roberts AI, Zhang L, Zheng B, Wen T, Han Y, Rabson AB, Tischfield JA, Shao C, Shi Y. 
  10. Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells. Nature Cell Biology. 2019 May;21(5):560-567. Nakahara F, Borger DK, Wei Q, Pinho S, Maryanovich M, Zahalka A, Suzuki M, Cruz CD, Wang Z, Xu C, Boulais PE, Ma'ayan A, Greally J, Frenette PS. 
  11. CD11b Regulates obesity-induced insulin resistance via limiting alternative Activation and proliferation of adipose tissue macrophages. Proceedings of the National Academy of Sciences of the United States of America. 2015 Dec;112(52):E7239-48. Zheng C, Yang Q, Xu C, Shou P, Cao J, Jiang M, Chen Q, Cao Q, Han Y, Li F, Cao W, Zhang L, Zhang L, Shi Y, Wang Y.
  12. Transforming growth factor β promotes immune responses in the presence of mesenchymal stem cells. The Journal of Immunology. 2014 Jan;192(1):103-9. Xu C, Yu P, Han X, Du L, Gan J, Wang Y, Shi Y. (Highlighted in the “In This Issue” section). 
  13. miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. The Journal of Biological Chemistry. 2013 Apr;288(16):11074-9. Xu C, Ren G, Cao G, Chen Q, Shou P, Zheng C, Du L, Han X, Jiang M, Yang Q, Lin L, Wang G, Yu P, Zhang X, Cao W, Brewer G, Wang Y, Shi Y. 
  14. Mesenchymal stromal cells equipped by IFNα empower T cells with potent anti-tumor immunity.Oncogene. 2022 Mar;41(13):1866-1881. Zhang T, Wang Y, Li Q, Lin L, Xu C, Xue Y, Hu M, Shi Y, Wang Y. 
  15. Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression. Developmental Cell. 2020 Jun 8;53(5):503-513.e5. Wei Q, Nakahara F, Asada N, Zhang D, Gao X, Xu C, Alfieri A, Brodin NP, Zimmerman SE, Mar JC, Guha C, Guo W, and Frenette PS. 
  16. MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells. Nature Communications volume 12, Article number: 2522 (2021). Wei Q, Pinho S, Dong S, Pierce H, Li H, Nakahara F, Xu J, Xu C, Boulais PE, Zhang D, Maryanovich M, Cuervo AM and Frenette PS.
  17. The good side of inflammation: Staphylococcus aureus proteins SpA and Sbi contribute to proper abscess formation and wound healing during skin and soft tissue infections. BBA-Molecular Basis of Disease. 2019 Oct;1865(10):2657-2670. Gonzalez CD, Ledo C, Cela E, Stella I, Xu C, Ojeda DS, Frenette PS, Gomez M. 
  18. The hematopoietic stem cell niche: from embryo to adult. Development. 2018 Jan;145(2). Gao X, Xu C, Asada N, Frenette PS. 
  19. Efficient presentation of multiple endogenous epitopes to both CD4+ and CD8+ diabetogenic T cells for tolerance. Molecular Therapy-Methods & Clinical Development. 2016 Dec;4:27-38. Dastagir SD*, Postigo-Fernandez J*, Xu C, Stoeckle J, Firdessa-Fite R, Creusot RJ. (* equal contribution).
  20. Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis. Oncogene. 2017 Feb;36(6):840-849. Yu P, Huang Y, Xu C, Lin L, Han Y, Sun W, Hu G, Rabson AB, Wang Y, Shi Y. 
  21. Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells. Oncogene. 2016 Nov;35(46):5953-5962. Shou P, Chen Q, Jiang J, Xu C, Zhang J, Zheng C, Jiang M, Velletri T, Cao W, Huang Y, Yang Q, Han X, Zhang L, Wei L, Rabson AB, Chin YE, Wang Y, Shi Y. 
  22. SHP1 regulates bone mass by directing mesenchymal stem cell differentiation. Cell Report. 2016 Jul;16(3):769-80. Jiang M, Zheng C, Shou P, Li N, Cao G, Chen Q, Xu C, Du L, Yang Q, Cao J, Han Y, Li F, Cao W, Liu F, Rabson AB, Roberts AI, Xie W, Wang Y, Shi Y. 
  23. Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? Cell Death Differentiation. 2016 Jul;23(7):1128-39. Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, Cao J, Xie N, Velletri T, Zhang X, Xu C, Zhang L, Yang H, Hou J, Wang Y, Shi Y. 
  24. Interleukin-17A enhances immunosuppression by mesenchymal stem cells. Cell Death and Differentiation. 2014 Nov;21(11):1758-68. Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Chen Q, Xu G, Zhang Y, Schneider R, Qian Y, Wang Y, Brewer G, Shi Y. 
  25. SSChighCD11bhighLy-6ChighLy-6Glow myeloid cells curtail CD4 T cell response by inducing nitric oxide synthase in murine hepatitis. The International Journal of Biochemistry & Cell Biology. 2014 Sep;54:89-97. Zhu K, Zhang N, Guo N, Yang J, Wang J, Yang C, Yang C, Zhu L, Xu C, Deng Q, Zhu R, Wang H, Chen X, Shi Y, Li Y, Leng Q. 
  26. Huang Y, Yu P, Li W, Ren G, Roberts A, Cao C, Zhang X, Su J, Chen X, Chen Q, Shou P, Xu C, Du L, Lin L, Xie N, Zhang L, Wang Y, Shi Y. p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation. Oncogene. 2014 Jul;33(29):3830-8.
  27. Mesenchymal stem cells prevent restraint stress-induced lymphocyte reduction via Interleukin-4. Brain, Behavior, and Immunity. 2014 May;38:125-32. Cao G, Yang Q, Zhang S, Xu C, Wang Y, Shi Y. 
  28. An osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells. 2014 Feb;32(2):327-37. Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts, A, Robson A, Ren G, Zhang Y, Wang Y, Denhardt D, Shi Y. 
  29. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Research. 2010 May;20(5):510-8. Shi Y, Hu G, Su J, Li W, Chen Q, Shou P, Xu C, Chen X, Huang Y, Zhu Z, Huang X, Han X, Xie N, Ren G. 
  30. A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles. Virology. 2009 Dec;395(1):67-76. Tao W, Xu C, Ding Q, Li R, Xiang Y, Chung J, Zhong J. 
  31. The research of the relationship between cyclooxygenase-2 and monocyte endothelial cells adhesion. Chinese Journal of Laboratory Diagnosis. 2013 Nov; 17(10). Wang H, Xu C, Cai F, Cao J, Chen X, Wu F. 
  32. Randomized Phase 2 trial of Intravenous Gamma Globulin (IVIG) for the Treatment of Acute Vaso-Occlusive Crisis in Patients with Sickle Cell disease: Lessons Learned from the Midpoint Analysis. Complementary Therapies in Medicine, 2020 Aug; Volume 52, 102481. Manwani D, Xu C, Lee SK, Amatuni G, Cohen H, Carullo V, Morrone K, Davila J, Shi PA, Ireland K, Keenan J, Frenette PS.

  33. Haematopoietic stem cell numbers are not solely determined by niche availability. Nature. In press. Takeishi S, Marchand T, Koba WR, Borger DK, Xu C, Guha C, Bergman A, Frenette PS, Gritsman K, Steidl U. 

  34. Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow. Nature Communications. 2018 Jun;9(1):2449. Xu C, Gao X, Wei Q, Nakahara F, Zimmerman SE, Mar J, Frenette PS.

  35. Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage. Journal of Experimental Medicine, 2021. 218 (1): e20200065.Xu C, Gulinello M, Frenette PS. Highlighted by Science Translational Medicine:A spicy solution for sickle cell disease. 

  36. IFNα-secreting MSCs exerts potent anti-tumor effect in vivo. Oncogene. 2014 Oct;33(42):5047-52. Xu C, Lin L, Cao G, Chen Q, Shou P, Huang Y, Han Y, Wang Y, Shi Y. 

主要承担课题及人才项目

  1. 中组部，海外高层次人才青年项目，2023-2025，在研，主持；
  2. 国家自然科学基金委员会, 重大研究计划培育项目, 2022-2024, 在研, 主持；
  3. 国家自然科学基金委员会, 面上项目，2023-2026, 在研, 主持；
  4. 科技部，国家重点研发计划项目，MSC治疗移植物抗宿主病等重大疾病的监管和评价的技术体系研究，2022-2027, 在研，骨干；
  5. 科技部，国家重点研发计划项目，间充质干细胞在组织稳态维持与疾病发生中的作用机制及靶向干预治疗研究，2022-2027,在研，骨干；
  6. 广东省科学技术厅，广东省自然科学基金面上项目，2023-2026，主持
  7. 中山大学，百人计划中青年杰出人才项目，2022-2024，在研，主持；
  8. 中山大学，高校基本科研业务费-青年教师培育项目，2023-2023，在研，主持。