导师资格：博士生导师

所在教研室/单位： 中山医学院

E-mail：yangjianrong@mail.sysu.edu.cn

研究方向：遗传学、生物信息学、进化系统生物学

个人/课题组主页：https://scholar.google.com/citations?hl=en&user=FQMIW2AAAAAJ

(致有意加入本团队的同学：我们干湿实验都做，因此特别欢迎两方面都有经验的同学；请先通过阅读论文充分了解我们的研究方向，如您确定感兴趣，欢迎email与我联系，并在来信中说明感兴趣的方向、文章及原因)

个人简介 About me

三级教授，硕/博导，国家高层次引进人才青年项目(2017-2020)和优秀青年科学基金(2021-2023)获得者。主要研究方向为遗传学、生物信息学、进化基因组学、系统生物学。2006年本科毕业于中山大学生物技术与应用专业（第二专业：计算机科学）。2011年于中山大学取得生化与分子生物学博士学位。2010至2016年于美国密歇根大学生态与进化生物学系任访问学者与博士后。2016年起任中山医学院教授。迄今已发表SCI论文44篇，其中作为（共同）通讯作者21篇，发表在Cell，Nature Ecology & Evolution(2篇)，Lancet Microbe，Nature Communications(3篇)，Advanced Science，Hepatology，Molecular Biology & Evolution(3篇)等国际一流杂志发表论文。

I am a professor in Department of Biomedical Informatics, Zhongshan School of Medicine, Sun Yat-sen University.  My research interests can be broadly categorized under Genetics, Evolutionary Genomics, Systems Biology and Bioinformatics. I got my Bachelor's degree in 2006 from the School of Life Science, Sun Yat-sen University, with first major in Applied Biotechnology and second major in Computer Science. Then I got my Ph.D. from Sun Yat-sen University in 2011 under the supervision of Prof. Shi-Mei Zhuang, and did post-doctoral research with Prof. Jianzhi "George" Zhang in Department of Ecology and Evolution, University of Michigan. I joined Zhongshan School of Medicine as a professor in 2016. As a (co-)corresponding author, my work has been published on Cell, Nature Ecology & Evolution(*2)，Lancet Microbe，Nature Communications(*3)，Advanced Science，Hepatology，Molecular Biology & Evolution(*3), etc.

研究方向 Research Interests

我们整合干/湿实验手段，长期聚焦分子进化基本动力及其互作规律，研究进化的可预测性及其应用，在病原体进化预测、体细胞演化规律、突变率与突变效应偏好等取得系列研究成果。关于研究课题的更多信息请参阅我们已发表的文章（见下方），或参见我在知乎的专栏。
With the long-term goal of enhancing the predictability of evolution and its biomedical applications, we study the driving forces behind molecular evolution and their interactions by integrating computational and experimental approaches. Our research allows us to predict pathogen evolution, reveal the general rules of somatic evolution, and elucidate how mutational bias impacts evolution and human health. For more information about our research topics, please refer to our published articles below.

学术成果

10篇代表学术论著（完整论著列表请见 https://orcid.org/0000-0002-7807-9455）
Ten selected publications：(Full list of pulications can be found on https://orcid.org/0000-0002-7807-9455)
(*: Corresponding author; #: Authors with equal contribution)

  1. Linjin Fan#, Yulong Wang#, Yinghao Wang#, Zequn Wang, Xiaofeng Yang, Chudan Liang, Nan Liu, Jun Zheng, Weifang Kang, Pengfei Ye, Pei Sun, Wendi Shi, Xinyi Guo, Weijian Wu, Jian-Rong Yang*, Quan Liu*, Linna Liu*, Jun Qian*; Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018–2020 epidemic; Cell; 2026; 189(1): 1-14
  2. Boyang Zheng#, Weijie Zhang#, Gongwang Yu#, Wenjun Shi, Shuyun Deng, Xiaoyi Zhang, Jingyu Chen, Ziwei Zhou, Yuyan Shan, Wanting Wu, Erping Long, Xiaoshu Chen*, Jian-Rong Yang*; Translational Fidelity and Longevity are Genetically Linked; Nature Communications; 2025; 16:7521 (13 pages) (Editors’ Highlights for “Genetics, genomics and epigenetics”)
  3. Xiaoyu Zhang#, Zizhang Li#, Jingyu Chen#, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen Jian-Rong Yang*; Stereotyped Subclones Revealed by High Density Single-Cell Lineage Tracing Support Robust Development; Advanced Science; 2025; 12(30): 2406208 (19 pages) (Highlighted as Frontispiece)
  4. Ziyan Guo#, Siyuan Feng#, Lujie Liang#, Zhuoxing Wu#, Lulu Min, Ruizhi Wang, Jiachen Li, Lan-Lan Zhong, Hui Zhao, Xiaoshu Chen*, Guo-Bao Tian*, Jian-Rong Yang*; Reversibility of resistance in the absence of antibiotics and its relationship with the resistance gene's fitness cost – a genetic study with mcr-1; Lancet Microbe; 2024; 5(8):100846 (11 pages)
  5. Gongwang Yu#, Yao Liu#, Zizhang Li, Shuyun Deng, Zhuoxing Wu, Xiaoyu Zhang, Wenbo Chen, Junnan Yang, Xiaoshu Chen, Jian-Rong Yang*; Genome-wide probing of eukaryotic nascent RNA structure elucidates cotranscriptional folding and its antimutagenic effect; Nature Communications; 2023; 14:5853 (18 pages)
  6. Feng Chen#, Zizhang Li#, Xiaoyu Zhang, Peng Wu, Wenjing Yang, Junnan Yang, Xiaoshu Chen, Jian-Rong Yang*; Phylogenetic comparative analysis of single-cell transcriptomes reveals constrained accumulation of gene expression heterogeneity during clonal expansion ; Molecular Biology and Evolution; 2023; 40(5): msad113 (20 pages)
  7. Zhuoxing Wu#, Xiujuan Cai#, Xin Zhang, Yao Liu, Guo-bao Tian, Jian-Rong Yang*, Xiaoshu Chen*; Expression level is a major modifier of the fitness landscape of a protein coding gene ; Nature Ecology and Evolution; 2022; 6(1): 103-115
  8. Feng Chen, Peng Wu, Shuyun Deng, Heng Zhang, Yutong Hou, Zheng Hu, Jianzhi Zhang*, Xiaoshu Chen*, Jian-Rong Yang* ; Dissimilation of synonymous codon usage bias in virus-host coevolution due to translational selection ; Nature Ecology and Evolution; 2020; 4(3);  589-600  (F1000 highlighted “Very good")
  9. Meng Yuan#, Xujiang Yang#, Jinghua Lin#, Xiaolong Cao#, Feng Chen, Xiaoyu Zhang, Zizhang Li, Guifeng Zheng, Xueqin Wang, Xiaoshu Chen*, Jian-Rong Yang*; Alignment of Cell Lineage Trees Elucidates Genetic Programs for the Development and Evolution of Cell Types; iScience; 2020; 23(7); 101273 (17 pages)
  10. Jianzhi Zhang*, Jian-Rong Yang; Determinants of the rate of protein sequence evolution; Nature Reviews Genetics; 2015; 16(7): 409-420

科研项目 Fundings

  1. 国自然国际（地区）合作与交流项目 “用于细胞类型的进化和发育起源研究的数据库开发”（主持；2024-2026）
  2. 国自然优秀青年科学基金项目“进化基因组学”（主持；2022-2024）
  3. 国自然面上项目 “细胞发育谱系树比对算法的设计与应用”（主持；2019-2022）

获奖荣誉

实验室成员所获荣誉/项目 Honors/grants won by group members

  • 郭梓妍（2022级硕士生）中山大学2025年优秀硕士学位论文
  • 吴卓幸（2017级硕博连读生） 2021年博士研究生国家奖学金；中山大学2022年优秀博士学位论文（在毕业典礼上作为学生代表发言）；中山大学中山医学院2021年生物信息学研究生论坛一等奖
  • 陈家璧（2020级硕博连读生） 2021年硕士研究生国家奖学金；中山大学中山医学院2021年生物信息学研究生论坛二等奖，2020年广东光大升学深造奖学金；2025年SMBE Young Investigtor Attendance Award
  • 桂倩（2018级硕士研究生） 中山大学2021年优秀硕士学位论文
  • 吴鹏（2019级硕博连读生） 2020年硕士研究生国家奖学金
  • 陈锋（2018博士后-2021特聘副研究员-2024副教授） 国自然青年科学基金（2020），面上项目（2022）资助

学术任职 Professional Memberships/services

国际进化与分子生物学会 Society of Molecular Biology and Evolution 会员
国际变异效应图谱联盟 Atlas of Variant Effects (AVE) Alliance 数据协调与传播工作组 Data Coordination and Dissemination (DCD) workstream 成员
中国遗传学会 会员
中国生物工程学会 会员
国际计算生物学学会中国分会 ISCB-China 理事

Editorial Board member: Journal of Genetics and Genomics (2020-now); Frontiers in Ecology and Evolution (2020-now); Frontiers in Genetics (2020-now); iMeta (2024-now)

Ad hoc reviewer for Nature; Nature Ecology and Evolution; National Science Review; Nature Communications; Advanced Science; Molecular Biology and Evolution; Aging Cell; Genome Biology; EMBO Reports; PLoS Genetics; PLoS Computational Biology; iScience; BMC Genomics;  Genome Biology and Evolution; Evolution;  BMC Evolutionary Biology;  Infection, Genetics and Evolution; iScience; Journal of Gene Medicine; Journal of Molecular Evolution; Journal of Theoretical Biology; PLoS ONE; Scientific Reports.