导师资格：博士生导师

所在教研室/单位： 免疫学教研室

E-mail：zhangp36@mail.sysu.edu.cn

办公电话：020-87331938

研究方向：宿主与病毒的相互关系；抗病毒药物的筛选。

个人简介 

2002-2004年，美国弗吉尼亚州立大学（VCU），博士后培训；

2005-2008年，美国加利福尼亚大学（UCSB），研究助理；

2009年-至今，  中山大学中山医学院，百人计划引进人才。曾获中山大学优秀青年教师、合生珠江优秀青年教师等称号。

研究方向

  1. 宿主与虫媒病毒（登革病毒、寨卡病毒等）的互作
  • 寻找参与病毒复制、感染与致病的关键宿主因子，阐明作用机制，为抗病毒药物提供靶点
  • 细胞抵抗病毒感染的应答，包括固有免疫应答、细胞死亡、未折叠蛋白反应、应急颗粒形成等的机制
  • 揭示病毒如何利用宿主元件、逃逸宿主细胞免疫防御的分子机理

2. 抗病毒药物的筛选。筛选具有抗病毒活性的小分子药物，阐明它们的作用机制。

近年来发表的通讯作者（共同通讯作者）文章

  1. Fei Feng# , Jiannan Chen #, Rong Li #, Yunkai Zhu#, Yanlong Ma, Ziqiao Wang, Yuyan Wang, Zhichao Gao, Lulu Yang, Yin Yu, Yanfeng Liu, Yingjie Sun, Ying Liao, Xinxin Huang, Qisheng Zhang, Yongheng Huang, Lin Qiu, Jiayu Wu, Jingxian Zhao, Chao Liu, Qiang Ding, Youhua Xie, Zhenghong Yuan, Yue Hong*, Ping Zhang*, Jing Sun*, Jincun Zhao*, Rong Zhang*. DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication. mBio. 2025:e0038525. doi: 10.1128/mbio.00385-25.
  2. Jinna Yang#, Changbai Huang#, Yao Feng, Junfang He, Yang Liu, Ping Zhang*, Chao Liu*. Adaptor protein complex 1 gamma 1 subunit is an important host factor involved in both Zika virus and Dengue virus infections.Virologica Sinica. 2025, S1995-820X(25)00107-5. doi: 10.1016/j.virs.2025.07.012.
  3. Xiaotong Luo, Yunxiang Yuan, Xiaocao Ma, Xin Luo, Jiannan Chen, Cancan Chen, Xiaoyi Yang, Jinna Yang, Xuanfeng Zhu, Meiyu Li, Yang Liu, Ping Zhang*, Chao Liu*. Diacylglycerol O-acyltransferase 2, a Novel Target of Flavivirus NS2B3 Protease, Promotes Zika Virus Replication by Regulating Lipid Droplet Formation. Research, 2024, 7:0511. doi: 10.34133/research.0511.
  4. Zhiting Huo#, Xuanfeng Zhu#, Cancan Chen, Qinyu Peng, Xiaoyi Yang, Changbai Huang, Yincheng Xiang, Yanxia Huang, Qingju Tian, Chao Liu*, Ping Zhang*. LINC08148 promotes the caveola-mediated endocytosis of Zika virus through upregulating transcription of Src. Journal of Virology, 2024, 98(6):e0170523.
  5. Yanxia Huang#, Qinyu Peng#, Xu Tian#,Cancan Chen, Xuanfeng Zhu, Changbai Huang, Zhiting Huo, Yang Liu, Chao Yang*, Chao Liu*, Ping Zhang*. Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1. Nature Communications，2024, 15(1):296
  6. Changbai Huang, Fei Feng, Yongxia Shi, Wenhui Li, Ziqiao Wang, Yunkai Zhu, Shuai Yuan, Dandan Hu, Jun Dai, Qiqi Jiang, Rong Zhang, Chao Liu*, Ping Zhang*. Protein Kinase C inhibitors reduce SARS-CoV-2 replication in cultured cells. Microbiology Spectrum, 2022, e0105622
  7. Shili Zhou, Quanshi Lin, Changbai Huang, Xiaocao Ma, Xiaotong Luo, Xu Tian, Chao Liu*, Ping Zhang*. Rottlerin plays an antiviral role at early and late steps of Zika virus infection. Virologica Sinica. 2022, 37 (5) 685–694
  8. Huixin Gao#, Yuxia Lin #, Changbai Huang#, Xiaobo Li, Michael S. Diamond, Chao Liu, Rong Zhang*, and Ping Zhang*.A genome-wide CRISPR screen identifies HuR as a regulator of apoptosis induced by dsRNA and virus. Journal of Cell Science, 2022, 135(6): jcs.258855
  9. Yuxia Lin#, Changbai Huang #, Huixin Gao, Xiaobo Li, Quanshi Lin, Shili Zhou, Zhiting Huo, Yanxia Huang, Chao Liu*, Ping Zhang*. AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. Journal of Cell Science, 2021, 135(1):jcs258910
  10. Yi Wang, Zhiting Huo, Quanshi Lin, Yuxia Lin, Cancan Chen, Yanxia Huang, Changbai Huang, Junfang He, Chao Liu*, Ping Zhang*. Positive feedback loop of lncRNA OASL-IT1 and innate immune response restricts the replication of Zika virus in epithelial A549 cells. Journal of Innate Immunity, 2021,13(2):1-15
  11. Yanxia Huang#, Quanshi Lin#, Zhiting Huo, Cancan Chen, Shili Zhou, Xiaocao Ma, Huixin Gao, Yuxia Lin, Xiaobo Li, Junfang He, Ping Zhang*, and Chao Liu*. Inositol requiring enzyme 1α promotes Zika virus infection through regulating stearoyl-CoA desaturase 1 mediated lipid metabolism.  Journal of Virology, 2020, 94(23):e01229-20
  12. Quanshi Lin#, Shili Zhou#, Yanxia Huang, Zhiting Huo, Cancan Chen, Xin Luo, Junfang He, Chao Liu*, and Ping Zhang*. ANKS4B restricts replication of Zika virus by downregulating the autophagy. Frontiers in Microbiology, 2020, 11:1745.
  13. Shili Zhou, Chao Yang, Fanfan Zhao, Yanxia Huang, Yuxia Lin, Changbai Huang, Xiaocao Ma, Jingjie Du, Yi Wang, Gang Long, Junfang He, Chao Liu*, and Ping Zhang*. Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR. Journal of Biological Chemistry, 2019, 294(48):18168-18180.
  14. Yi Wang#, Xiaoyan Chen#, Jiong Xie, Shili Zhou, Yanxia Huang, Yiping Li, Xiaobo Li, Chao Liu, Junfang He*, Ping Zhang* . RNA helicase A is an important host factor involved in dengue virus replication. Journal of Virology, 2019, 93(4): e01306-18

  15. Huixin Gao#, Yuxia Lin#, Junfang He, Shili Zhou, Mujiao Liang, Changbai Huang, Xiaobo Li, Chao Liu*, Ping Zhang*. Role of heparan sulfate in the Zika virus entry, replication, and cell death. Virology, 2019, 529: 91-100

     

主持项目

  1. 国家自然科学基金面上项目，32470986，宿主犹素修饰系统通过增强固有免疫应答发挥抗登革病毒作用的研究
  2. 广东省自然科学基金面上项目，2024A1515010471，被寨卡病毒募集至内质网的宿主蛋白的筛选与功能研究
  3. 国家自然科学基金面上项目，82271385, 核膜蛋白SUN2在寨卡病毒致神经系统疾病中的作用机制研究
  4. 广州市科技局重点研发计划，202206010114, 抗RNA病毒药物的机理与应用研究
  5. 广东省自然科学基金面上项目，2021A1515011491，基于CRISPR/Cas9技术筛选寨卡病毒的宿主因子与功能研究
  6. 国家自然科学基金面上项目，31970887,一个新的长链非编码RNA通过正反馈调控干扰素的产生抑制寨卡病毒的复制
  7. 广东省科技计划项目, 2017A050501012, RNA编辑酶ADAR1促寨卡病毒复制的分子机制研究
  8. 国家自然科学基金面上项目，81371794，Notch 受登革病毒调控的分子机制及其对固有免疫和病毒复制的影响
  9. 国家自然科学基金面上项目，81171576，PKR在登革病毒诱导干扰素合成过程中的调控作用与分子机制

  10. 国家自然科学基金青年项目，30901345，与 PKR 蛋白激酶相互作用的先天免疫相关蛋白的鉴定和功能分析

     

学术兼职

  • American Society for Virology 会员
  • Journal of Interferon & Cytokine Research 副主编
  • 《中山大学学报》《热带医学杂志》编委